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Flash Purification & Work-up Tools from Biotage®
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From synthesis to purification, Biotage delivers innovative solutions to streamline your work process, enabling you to reach your purification goals faster and easier.
The new IsoleraTM Dalton is a fully automated miniaturized mass directed flash purification system. The new system raises the bar for flash purification by integrating, for the first time, a miniaturized mass detector and an advanced flash chromatography system into one commercially available platform.
Isolera™ Spektra has intelligent, time-saving features such as gradient optimization, λ-All peak detection and real-time photodiode array (PDA) scanning. Isolera Spektra enable chemists to purify more compounds in less time and reduce post-process purity analysis. Isolera Spektra doubles chemists’ productivity while slashing purification costs 20% or more. Read more »
Product Overview
IsoleraTM Dalton
Isolera Dalton is a fully automated miniaturized mass directed flash purification system. The Dalton mass detector and Isolera Spektra flash purification system are seamlessly integrated via the Isolera Dalton Nanolink unit, an intelligent sampling device which handles all fluids and synching calculations between the two units. Isolera Dalton easily fits inside a standard fume hood, requires no external pumps and is capable of both normal and reverse-phase separations, so it is completely compatible with the diverse purification needs of the modern research laboratory.
IsoleraTM Prime
Isolera Prime is the new standard in value-priced flash purification systems delivering a full range of features and cost-saving benefits. This flexible system is upgradeable and grows with the needs of laboratories and universities where value is especially important. Isolera Prime is compatible with Biotage flash cartridges, including the new value-priced Biotage ZIP.
IsoleraTM Spektra One and Four
Isolera Spektra, a modern flash purification system with intelligent features, enables chemists to easily achieve better separations. The TLC-to-step feature automatically creates elution gradients and suggests cartridge and sample size. Collect fractions at all wavelengths, adjust the flow rate from 1 to 200 mL/min as needed and use up to four solvents in a single gradient, for maximum purity and yield.
IsoleraTM Spektra LS
Isolera Spektra LS development-scale flash purification system dramatically shortens large-scale purification run-times with flow rates of 50-500 mL/minute. Simply select or create a method, load your sample, and run – it’s that easy. New advanced features include: the ability to collect fractions on all wavelengths, use of up to four solvents in a single gradient and add a third isocratic co-solvent. A UV-VIS detector increases detection to 200-800nm.
IsoleraTM ELSD-1080
Isolera ELSD (evaporative light-scattering detector) is a universal detector designed for use with Isolera flash purification systems when purifying organic compounds that are undetectable UV or visible light. Flash chromatography with detection and fractionation is now possible when purifying carbohydrates, steroids, lipids, terpenes and other UV-transparent compounds.

View the Isolera Systems demo video with Senior Product Manager Bob Bickler.
Biotage FlashMaster Personal Plus
The Biotage FlashMaster Personal Plus is a simply easy-to-use, pump-driven, dual cartridge, manual flash purification system, With a flow rate range of 5–240 mL/min, purification can be done in a flash. Tis small footprint design uses minimal bench space and allows direct attachment of Biotage flash cartridges.
Flash 75 and 150
Designed for rapid, efficient gram-scale (1-320g) purifications. Their operation requires no electricity or computer control- just compressed air to push solvent through the cartridge and to exert radial compression on the cartridge. The patented radial compression technology reduces the chance of void and channel formation, resulting in a higher bed density. Compounds can be collected in narrower bands for higher purity and yield.