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Biotage® Initiator+
Microwave Synthesizer

Features and Advantages

  • 300 °C reaction temperature
  • 30 bar reaction pressure
  • In situ temperature measurement
  • Upgradable to run peptide synthesis
  • Large 10" touchscreen
  • Modular automation solutions
  • Guided step-by-step wizard
  • Safe and simple
Initiator+

Rapid, microwave-assisted organic synthesis for
processing and method development

The Biotage Initiator+ represents a new generation of instruments for organic, medicinal, materials, nano and polymer chemistry professionals. It is an upgradeable and reliable platform for chemists to make great discoveries.

Initiator+ The Biotage Initiator+ is a flexible system that utilizes all Biotage vials, from 0.2 to 20 mL, in any order or combination, at any time without system modifications, delivering greater flexibility and direct scale-up from milligrams to grams.

Biotage Initiator+ can also be upgraded with automation solutions to achieve higher throughput to save time and cost.

Flexibility
Higher temperatures and pressures of up to 300 °C and 30 bar open new possibilities to perform difficult reactions. This allows for more flexibility in choosing a solvent. Even low boiling point solvents can now be run at higher temperatures. Using “Regulate on pressure” enables the reaction to reach highest possible temperature during the run. With the addition of the optional fiber optic probe, it is possible to measure the reaction temperature inside the vial for a higher degree of control.

Upgradable
Upgrade from an Biotage Initiator+ by connecting the SP Wave peptide synthesis module and the Robot Eight kit to perform microwave assisted peptide synthesis with vortex mixing to ensure homogeneous heat distribution.

Easy to operate
The large touch screen display provides an easy-to-use experience from set-up to results. By using the Biotage Wizard, the user is guided through the set-up of experiments step-by-step. It also includes assistance in converting conventional conditions to microwave synthesis parameters.

Modular
The modular design allows a user to add on different automated sample processors dependent on throughput requirements.

Safe
The reaction vessel is secured with a triple-tier safety lock to ensure maximum operator safety at all times. This in combination with high grade aluminum and a safe explosion box ensures maximum operator safety, even at high temperature and pressure.

Specifications

Heating Process  
Temperature range 40–300°C1
Temperature increase Typically 2-5 °C/sec depending on solvent and
power applied
Reaction time Up to 96 hours.
  Typically, most reactions require 2 to 15 minutes of irradiation.
Pressure range 0–302 bar (3 MPa; 435 psi)
Power range 0–400 W from magnetron at 2.45 GHz
Reaction volumes 0.2–20 mL
Agitation Variable magnetic stirrer (300-900 RPM)
   
Sample Processor  Upgradable with Robot Eight / Robot Sixty
   Processing capacity 8 vials / 60 vials
   Rack capacity (large) 2x2 vials / 2x12 vials
   Rack capacity (small) 2x4 vials / 2x30 vials
   
System Requirements  
Temperature Operating Temperature: 18–32°C
  Storage and transportation temperature:
-25°C to 60°C
Humidity 20–95% at room temperature
Electrical supply Europe: 220–240 V~, 50 Hz (5 A)
  US and Japan: 100–120 V~, 50/60 Hz (10 A)
Maximum power consumed 1100 VA
Cooling Pressurized air supply: > 60 l/min
(2.1 cubic feet/min), 2.5 to 4.0 bar
  (0.25 to 0.40 MPa; 36 to 58 psi)
 Weight Initiator+: 21 kg (48.5 lbs)
 Dimensions (WxDxH) Initiator+:
365 x 422 x 421 mm (14.4"x 16.6" x 16.6")
 Max sound level 70 dB(A)
   
 Interfaces  
 Touch screen  10.4"
 Ethernet LAN  Complies with IEEE 802.3 (ANSI 8802-3)
 USB  USB 2.0
 Achiving/back-up  Via USB
 Printing  Via LAN
   
 Upgrade Path The Initiator system can be upgraded to an automated 8- or 60-position system, it can also be equipped with the SP Wave module for an automation solution for peptide chemistry, complete with vortex mixer and liquid handling.
   
 Certifications CE, CSA certified

1Temperature range is limited to 40–250°C for the 10-20 mL vessel
2Pressure range is limited to 0-20 bar for the 10-20 mL vessel


Ordering Information

Part Number Description
356006 Biotage Initiator+ System (EU)
356007 Biotage Initiator+ System (USA/JPN)
355380 Robot Eight for Initiator System 
355381 Robot Sixty for Initiator System
356014 Biotage Initiator+ SP Wave Microwave Peptide System (EU)
356015 Biotage Initiator+ SP Wave Microwave Peptide System (USA/JPN)
Optional Accessories and Consumables
355458 Microwave Vials 0.2-0.5 mL, qty 100
352016 Microwave Vials 0.5-2 mL, qty 100
351521 Microwave Vials 2-5 mL, qty 100
354833 Microwave Vials 10-20 mL, qty 50
   
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