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Initiator+ SP Wave
Microwave Peptide Synthesizer

Versatile synthesis solution
The Biotage® Initiator+ SP Wave is a programmable synthesis system that can be configured to perform either microwave assisted peptide or organic synthesis.
In peptide synthesizer mode, this is the perfect tool for chemists synthesizing peptides and peptidomimetics, including difficult modifications and labelling of sequences, by using single or multi-step procedures. The intuitive Initiator 4.0 software controls the instrument functions and by using the pre-defined methods synthesis can be started immediately.
Benefit from the ability to perform reactions using microwave irradiation on a small scale. The semi-automated operation also reduces the consumption and waste of expensive reagents which occur in other systems due to priming of the system or use of large dead volumes.
Features and Advantages
- Microwave assisted peptide and organic synthesis
- Semi-automated
- Disposable 2, 5 and 10 mL PP-reactor vials with PTFE frits
- Synthesis on 5-300 µmol scale
- Large 10” touchscreen
- Inert gas capability
- Easy-to use Initiator 4.0 software
- Use pre-defined methods or define your own
- Vortex mixing in peptide synthesis mode
- Magnetic stirring in organic synthesis mode
- Single robot arm and digital syringe pump
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The intuitive interface provides complete control of the process
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Perform small scale microwave synthesis by using single or multi step procedures |
Versatile
Use as a standalone peptide synthesizer or easily convert to a high specification MAOS system. Ideal for the synthesis of, peptides, peptidomimetics, PNA and for organic, medicinal, materials, nano and polymer chemistry applications.
Complete control
Automate the deprotection and washing steps and manually add activated building blocks to give the user complete control over all reaction steps. Easily monitor intermediate reaction steps, failure of which would only be identified upon completion of the synthesis.
Reduce costs
When using expensive reagents such as PNA monomers or glycoamino acids, you can manually add the exact amount of reagent while minimizing waste and costs. Save even more by benefiting from the ability to perform synthesis on a small scale from as low as 5 µmol.
Synthesize Difficult Sequences
Use microwave irradiation and standard reagents to synthesize difficult sequences that are problematic or even impossible to synthesize using conventional methods.
Dual mode of mixing
In peptide synthesis mode, use efficient vortex mixing within the microwave cavity to ensure homogeneous heat distribution, and by magnetic stirring when used in organic synthesis mode of operation.
Specifications
| Heating Process |
| Temperature range |
40–100 °C |
| Temperature increase |
Typically 2-5 °C/sec |
| Pressure range |
Run at atmospheric pressure |
| Power range |
0.200 W at 2.45 GHz, capped at 60 W during steady state |
| Reactor vial sizes |
2, 5 and 10 mL |
| Agitation |
Variable vortex mixer (300-1300 rpm) |
| Vial volume range |
2 mL reactor vial: 0.8-1.1 mL 5 mL reactor vial: 1.6-3.2 mL 10 mL reactor vial: 3.2-6.4 mL |
| Inert gas (optional) |
Approximately 2 L/min (0.07 cubic feet/min), 2 bar (0.2 MPa; 29 psi) |
| Liquid Handling |
| Syringe Pump |
Digital single syringe pump, 11 mL w. sample loop |
| Volume range |
10 µL to 11 mL (< 1.0% deviation at full stroke) |
| Flow rate |
1-50 mL/min |
| Reagent bottle rack |
3 x 100 mL |
| System solvent |
1 x 2000 mL |
| Interfaces |
| Touchscreen |
10.4" |
| Ethernat LAN |
Complies with IEEE 802.3 (ANSI 8802-3 |
| USB |
USB 2.0 |
| Archiving/back-up |
Via USB |
| Printing |
Via LAN |
| System Requirements |
| Temperature |
Operating temperature 18-32 °C Storage and transportation temperature: -25 °C to 60 °C |
| Humidity |
20-95% at room temperature |
| Electrical supply |
Europe: 220-240 V~, 50 Hz (5 A) US and Japan: 100-120 V|, 50/60 Hz (10A) |
| Maximum power consumed |
1100 VA |
| Weight |
33 kg (72.7 lbs) |
| Dimensions (WxDxH) |
400 x 500 x 685 mm (15.7" x 19.7" x 27.0") |
| Vacuum pump |
Minimum partial pressure: 50 mbar (5 kPa; 0.7 psi) Flow rate: 30 l/min (1.1 cubic feet/min) |
| Certifications |
CE, CSA certified |
Ordering information
| Part Number |
Description |
| 356014 |
Initiator+ SP Wave (EU) |
| 356015 |
Initiator+ SP Wave (USA/Japan) |
| Optional Accessories and Consumables |
| V020TF051 |
PP-Reactor, 2 mL, with PTFE frit, 100/pk |
| V050TF062 |
PP-Reactor, 5 mL, with PTFE frit, 100/pk |
| V100TF086 |
PP-Reactor, 10 mL, with PTFE frit, 100/pk |
| E00VP001 |
Vacuum pump ME2C, 100-230 VAC |
| 356016 |
Waste and scrubber kit |