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Initiator SP Wave
Microwave Peptide Synthesizer

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Versatile synthesis solution

The Biotage® Initiator+ SP Wave is a programmable synthesis system that can be configured to perform either microwave assisted peptide or organic synthesis.

In peptide synthesizer mode, this is the perfect tool for chemists synthesizing peptides and peptidomimetics, including difficult modifications and labelling of sequences, by using single or multi-step procedures. The intuitive Initiator 4.0 software controls the instrument functions and by using the pre-defined methods synthesis can be started immediately.

Benefit from the ability to perform reactions using microwave irradiation on a small scale. The semi-automated operation also reduces the consumption and waste of expensive reagents which occur in other systems due to priming of the system or use of large dead volumes.

 

Features and Advantages

  • Microwave assisted peptide and organic synthesis
  • Semi-automated
  • Disposable 2, 5 and 10 mL PP-reactor vials with PTFE frits
  • Synthesis on 5-300 µmol scale
  • Large 10” touchscreen
  • Inert gas capability
  • Easy-to use Initiator 4.0 software
  • Use pre-defined methods or define your own
  • Vortex mixing in peptide synthesis mode
  • Magnetic stirring in organic synthesis mode
  • Single robot arm and digital syringe pump

 

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The intuitive interface provides
complete control of the process

Perform small scale microwave
synthesis by
using single or multi
step procedures

Versatile
Use as a standalone peptide synthesizer or easily convert to a high specification MAOS system. Ideal for the synthesis of, peptides, peptidomimetics, PNA and for organic, medicinal, materials, nano and polymer chemistry applications.

Complete control
Automate the deprotection and washing steps and manually add activated building blocks to give the user complete control over all reaction steps. Easily monitor intermediate reaction steps, failure of which would only be identified upon completion of the synthesis. 

Reduce costs
When using expensive reagents such as PNA monomers or glycoamino acids, you can manually add the exact amount of reagent while minimizing waste and costs. Save even more by benefiting from the ability to perform synthesis on a small scale from as low as 5 µmol.

Synthesize Difficult Sequences
Use microwave irradiation and standard reagents to synthesize difficult sequences that are problematic or even impossible to synthesize using conventional methods.

Dual mode of mixing
In peptide synthesis mode, use efficient vortex mixing within the microwave cavity to ensure homogeneous heat distribution, and by magnetic stirring when used in organic synthesis mode of operation.


Specifications

Heating Process  
Temperature range 40–100 °C
Temperature increase Typically 2-5 °C/sec
Pressure range Run at atmospheric pressure
Power range 0.200 W at 2.45 GHz, capped at 60 W during steady state
Reactor vial sizes 2, 5 and 10 mL
Agitation Variable vortex mixer (300-1300 rpm)
Vial volume range 2 mL reactor vial: 0.8-1.1 mL
5 mL reactor vial: 1.6-3.2 mL
10 mL reactor vial: 3.2-6.4 mL
Inert gas (optional) Approximately 2 L/min (0.07 cubic feet/min), 2 bar (0.2 MPa; 29 psi)
Liquid Handling 
Syringe Pump Digital single syringe pump, 11 mL
w. sample loop
Volume range 10 µL to 11 mL (< 1.0% deviation at full stroke)
Flow rate 1-50 mL/min
Reagent bottle rack 3 x 100 mL
System solvent 1 x 2000 mL
Interfaces 
Touchscreen 10.4"
Ethernat LAN Complies with IEEE 802.3 (ANSI 8802-3
USB USB 2.0
Archiving/back-up Via USB
Printing Via LAN
System Requirements 
Temperature Operating temperature 18-32  °C
Storage and transportation temperature: -25  °C to 60  °C
Humidity 20-95% at room temperature
Electrical supply Europe: 220-240 V~, 50 Hz (5 A)
US and Japan: 100-120 V|, 50/60 Hz (10A)
Maximum power consumed 1100 VA
Weight 33 kg (72.7 lbs)
Dimensions (WxDxH)  400 x 500 x 685 mm
(15.7" x 19.7" x 27.0")
Vacuum pump Minimum partial pressure: 50 mbar
(5 kPa; 0.7 psi)
Flow rate: 30 l/min (1.1 cubic feet/min)
Certifications CE, CSA certified


Ordering information

Part Number Description
356014 Initiator+ SP Wave (EU)
356015 Initiator+ SP Wave (USA/Japan)
Optional Accessories and Consumables
V020TF051                       PP-Reactor, 2 mL, with PTFE frit, 100/pk
V050TF062 PP-Reactor, 5 mL, with PTFE frit, 100/pk
V100TF086 PP-Reactor, 10 mL, with PTFE frit, 100/pk
E00VP001 Vacuum pump ME2C, 100-230 VAC
356016 Waste and scrubber kit

 

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