Biotage, Argonaut, Advantage Series 4100 process scale up reactor,

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Advantage Series^® 4100 Process Scale-up Reactor

Advantage Series 4100_300pix

Developed with the chemist in mind, the Advantage Series 4100 process scale-up reactor provides improved experimentation control while allowing the process chemist to quickly study results and plan for the next experiment.

Saves hours of hands-on time
Uses real-time feedback from analytics interfaces
Controls multiple reaction parameters from one interface

Simplify Process Scale-up
The Advantage Series 4100 process scale-up reactor for pharmaceutical compound development simplifies scale-up work by allowing chemists to program and control reaction conditions such as temperature, reagent addition amounts and rates, and stirring speed using a single computer running CamileTG® software. Using the Advantage Series multiple-parameter recipe editor, chemists can program the Advantage Series 4100 reactor to use real-time feedback from analytical instrumentation to automatically obtain optimum conditions for the formation of desired compounds, increasing yield and making more efficient use of time and materials.

Key Features
Configurable to Specific Needs
The Advantage Series 4100 reactor fits in a chemical fume hood and works with a variety of instrumentation for controlling reaction conditions and collecting analytical data. The Advantage Series 4100 reactor has the following standard features:

0.5, 1.0 or 2.0 L reactor
Overhead stirring system (0 to 2000 rpm)
Temperature control system (-25 to 150 °C)
Single liquid feed (0.1 to 10 mL/min, 1 to 50 mL/min or 5 to 250 mL/min)
Advantage Series 4100 software and hardware control system
Inert gas purge
Heat flow measurement system

21 CFR Part 11 Compliance
The 4100 reactor includes a number of features to support meeting the technical requirements of 21 CFR part 11 pertaining to closed systems. The 4100 reactor can produce an electronic record of activities pertaining to the reaction,whether they originate from the reaction recipe or from manual intervention, and create and save a recipe that enables the experiment to be reproduced automatically. This electronic data capture also links the data file to the operator with an electronic signature. Operators can link comments to the process run. The electronic record is marked with an encrypted time stamp and is archived using a method designed to comply with 21 CFR part 11 requirements. The 4100 reactor's operating system can integrate with any electronic signature package that can be embedded into Microsoft® Excel running under the Microsoft Windows® operating system, enabling integration into existing laboratory information infrastructures.

Under the 4100 reactor's operating system, system administrators assign authority levels to each operator. The 4100 reactor monitors and controls levels of access for those operators and performs checks for uniqueness of login names and passwords. Data pertaining to the validity of passwords and authority of users at the time a record is accessed are captured, linked with the document and encrypted in the audit trail of the document. Pharmaceutical companies can significantly reduce the time required for data collection and submission by implementing the 4100 reactor's features for technical compliance of closed systems within an environment of compliant operational strategies.