High-Throughput and Parallel Screening Methods in Asymmetric Hydrogenation
High-throughput and parallel screening methods are being used more and more extensively in various areas of chemistry, including enantioselective synthesis. This is due to the extremely small energy differences determining such critical factors as enantioselectivity.
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Developing an Efficient, Safe and Scaleable Process for the Synthesis of the Chiral Auxiliary (S)-4-(Phenylmethyl)-2-oxazolidinone
This paper presents the experimental results on chemical development of this reaction using new reactor instruments available to process R&D scientists.
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Precision and Accuracy Using the ChemCorder Workflow Replicator
The ChemCorder Workflow replicator accurately records actions that a chemist undertakes, and produces a recipe file that will precisely reproduce the recorded chemistry.
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Heat Flow Measurement as a Kinetic Probe
Heat flow measurements can track the extent of a reaction and can be used to determine kinetic constants. Kinetic constants calculated from thermal data measured with the Advantage Series 3400 workstation for the hydrolysis of acetic anhydride agreed with literature values (within 10%) that were measured using an absorbance method.
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Optimizing a Temperature-Sensitive Reaction for Scale-Up
The intricate parameter control and synchronous data capture capabilities of the Advantage Series 4100 enabled the DPR group to run consecutive, iterative reactions with minute variations, analyze the results, and accurately adapt the reaction for scale-up.
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Rapid Determination of Crystallization Metastable Zone Width
Crystallization affects every aspect of process chemistry, including process transfers, filtration, impurity purging, drying and particle size measurements.
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Activated Carbon Decolorization using Prepacked Disposable Cartridges
The removal of colored impurities (De-colorization) from natural products, organic and inorganic compounds at bench scale and industrial scale is commonly accomplished via batch charcoal absorption techniques. The de-colorization procedure can be more efficient, faster and easier using a pre-packed charcoal cartridge.
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Decolorization of Products with FLASH-AC™ (Activated Carbon Cartridges)
This paper demonstrates the variables to optimize a successful cartridge decolorization step using a synthetic mixture of phenol and methyl red. This paper also compares the decolorization results from a batch process and prepacked cartridge process.
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Removing Colored Impurities from 9-Fluorenylmethanol with FLASH-AC™
The variables to remove color using the FLASH-AC cartridges are discussed in the application note #12 titled Decolorization of Products with FLASH-AC. In this work these principles are applied decolorizing an organic synthesis intermediate. Removing the degradation products from an intermediate product is desirable to minimize the impurities formed in subsequent synthetic steps.
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Purifying Labile Reagents with FLASH-AC™ Cartridges
Purifying the reagents before synthesis significantly improves the color and purity of the final product. In practical applications the purification of a degraded reagent before synthesis will reduce or eliminate purification of the final product. Purification before the synthesis step prevents process losses of the final product. This process is ideal for degradable reagents since purification can be performed immediately before the synthesis.
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Removing Tannins from Plant Biomass Solutions with FLASH-AC™ Carbon Cartridges
The value of many harvested, plant-based compounds is negatively affected by the presence of highly colored tannins. Tannins are a series of polyphenol components that are traditionally removed by adsorption onto activated carbon, but this process using loose carbon media is awkward, especially in a cGMP environment.
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Comparing Granular and Powdered Activated Carbon Columns to FLASH-AC™ Cartridges
Adsorbent media efficiency is most effective when packed into cartridges. The particle size of the packed media affects cartridge performance. Packed cartridges containing granular carbon, powdered carbon, and conditioned carbon were evaluated for performance when packed into identical cartridges.
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