 |
|
Interim report January - June 2010
Biotage AB (publ) - disclosure notice of substantial holding of shares
Biotage appoints Anders Wikström as Vice President of Operations and Anthony Rees as Chief Scientific Officer
|

Biotage are Gold Sponsors.
5th - 9th September
Copenhagen, Denmark21st - 24th September
Basel, SwitzerlandAugust 27-28
Orlando, FL10th - 12th November
Montreux, Switzerland1st - 3rd December
Barcelona, Spain
|
|
| |
V-10 1.6 Evaporator Vortex and vacuum evaporation system

Quickly and safely dry dissolved compounds The Biotage V-10™ solvent evaporation system rapidly dries samples dissolved in both aqueous and organic solvents up to 20x faster than traditional rotary or centrifugal evaporators, leaving solvent-free product in the vial. This innovative vortex and vacuum evaporation technology was developed through collaboration with major pharmaceutical companies. The high performance vacuum capability of the V-10 allows low temperature evaporation of high boiling solvents. Optimized evaporation methods protect the sample against bumping and overheating. Versatility and scalability eliminate handling and reformatting issues.
Rapid three-way drying Evaporate samples up to 20x faster than traditional rotary or centrifugal evaporators using a patented combination of drying techniques, including high-speed vial rotation, uniform IR controlled heating, and vacuum drying. This unique system provides rapid evaporation of solvents with boiling points from 30 to 205 °C. Samples dried on a V-10 have little or no solvent residue to interfere with downstream analysis such as NMR.
Evaporation of high boiling solvents The V-10’s high performance vacuum capability allows low temperature evaporation of high boiling solvents. Solvents include DMF, aqueous, aqueous/organic mixtures and even DMSO and NMP with the high vacuum pump option (see table 1).
Solvent
|
BP (° C) |
Biotage V-10 evaporation |
Centrifugal evaporation |
Blow-down evaporation |
| NMP |
202 |
18 minutes |
N/A |
N/A |
| DMSO |
180 |
15 minutes |
180 minutes |
N/A |
| DMF |
150 |
4 minutes |
90 minutes |
N/A |
| Pyridine |
115 |
5.5 minutes |
70 minutes |
N/A |
| Water |
100 |
9 minutes |
140 minutes |
240 minutes |
| Methanol |
65 |
3 minutes |
70 minutes |
40 minutes |
| Cyclohexane |
81 |
2.5 minutes |
40 minutes |
20 minutes | Table 1. Time to evaporate 8-mL of solvent at 40º C using Hi Boil method
Versatility and Automation V-10’s versatility enables evaporation of single samples (up to 12 mL) or large pooled volumes using V-10 pumps (syringe or peristaltic). Adding the automated vial loading/changing carousel enables unattended evaporation of up to 16 samples. Using the V-10 Control Center software, integrate the system with a liquid handling robot. Combine multiple fractions/samples from different test tube racks and dry them into a single vial in one operation
Clean and safe evaporation Bump-free vortex evaporation prevents sample loss while the system’s precise temperature control eliminates sample overheating. Maximize sample recovery with the V-10’s automatic, end-of-run detection.
Eliminate Reformatting Compounds are dried directly in vial of choice. Tedious tasks such as sample transfers, handling and reformatting are minimized, increasing productivity in the lab.
Enhanced Green Chemistry This environmentally friendly system captures up to 98% of solvent vapors.
Simple Operation The system is operated via touchpad control or the via the Control Center software. On the base unit easy-to-use touchpad control directly provides pre-programmed and user-configurable methods for optimal drying conditions. The Control Center software provides simple simultaneous control of the V10 and the integrated liquid handler.
Compact footprint Localized key pad operation along with built-in, solvent-resistant vacuum pump and refrigerated condenser save valuable bench space.

|
System Specifications
|
|
|
Sample delivery
Vial size compatibility
Liquid Handling compatibility
System Requirements Power
Gas and Pressure limit
Dimensions (W x H x L)
Weight
Certifications
Interfaces Network connections
|
5-mL syringe pump and/or peristaltic pump
4 mL (3 variants)
20 mL scintillation vial
30 mL scintillation vial
Gilson 221 (use with peristaltic pump) Gilson 222, 215 or GX271 (use with dual pumps)
110 VAC (± 10%), 60 Hz, 15A (USA) 110 VAC (± 10%), 50/60 Hz, 15A (Japan) 230 VAC (± 10%), 50 Hz, 8A (EU/UK)
Compressed Nitrogen (optional) regulated up to a maximum of 2 bar
40 cm x 53 cm x 48 cm (16” x 21” x 18.5”) 49 cm x 53 cm x 54 cm (19.5” x 21” x 21.5”) 45 kg (100 lb) 50 kg (111 lb)
CE
Rs232 or TCP/IP Switched I/O
|
|
|
|
|
|
Print page
|
|
|
|
 |
|
|
|