Biotage Solution Phase Resin Selection Table. PS-Benzaldehyde, MP-Carbonate, PS-DEAM, PS-Isocyanate, MP-Isocyanate, PS-Thiophenol, MP-TMT, PS-Triphenylphosphine, PS-Trisamine, MP-Trisamine, PS-TsCl (High-Loading), PS-TsNHNH2, MP-Borohydride, PS-Carbodiimide, MP-Carbonate, MP-Cyanoborohydride, PS-DES, PS-DIEA, PS-DMAP, PS-HOBt(HL), PS-NMM, PS-PPh3-Pd, PS-TBD, MP-Triacetoxyborohydride, PS-Triphenylphosphine, PS-TsCl, MP-TsOH, MP-TsOH(65), MP-TsOH Cartridge, MP-TsO-TEMPO, ACTU PS-HOBt(HL), resin se

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Interim report January - June 2010

Biotage AB (publ) - disclosure notice of substantial holding of shares

Biotage appoints Anders Wikström as Vice President of Operations and Anthony Rees as Chief Scientific Officer

Biotage Introduces Resolux™ Peptides Purification HPLC Columns

New Isolera™ UV-VIS Flash Purification System delivers widest wavelength range available to chemists (Copy)

Biotage Launches New Isolera™ ELS Detector, Helps Isolate Virtually Any Compound

Biotage Introduces Highly-Selective ExploraSep 96-Well Screening Plates based on Molecularly Imprinted Polymers

Biotage Introduces Highly-Selective AFFINILUTE MIP

European Peptide SymposiumBiotage are Gold Sponsors.
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Barcelona, Spain

Solution Phase Resins Selection Table

Scavenger Products	Structure	Applications	Part Number
PS-Benzaldehyde 1.0 - 1.6 mmol/g (Click to download)		Scavenges nucleophiles; including primary amines, hydrazines, reducing agents	3 gm - 800502 10 gm -800360 25 gm - 800361 100 gm - 800362 1000 gm - 800363 Download Material Safety Data Sheet
MP-Carbonate 2.5 - 3.5 mmol/g (Click to download)		General base. Neutralizes ammonium salts, scavenges acids, acidic phenols	3 gm - 800493 10 gm - 800267 25 gm - 800268 100 gm - 800269 1000 gm - 800314 Download Material Safety Data Sheet
PS-DEAM 1.5 - 2.2 mmol/g (Click to download)		Scavenger for titanium (IV) chloride, titanium (IV) isopropoxide, boronic acids	3 gm - 800515 10 gm - 800430 25 gm - 800431 100 gm - 800432 1000 gm - 800433 Download Material Safety Data Sheet
PS-Isocyanate 1.0 - 1.7 mmol/g (Click to download)		Scavenging nucleophiles, including amines and alkoxides	3 gm - 800495 10 gm - 800260 25 gm - 800261 100 gm - 800262 1000 gm - 800311 Download Material Safety Data Sheet
NEW and Improved! MP-Isocyanate 1.0 - 2.0 mmol/g (Click to download)		Scavenging nucleophiles, including amines and alkoxides	3 gm - 801504 10 gm - 801409 25 gm - 801410 100 gm - 801411 1000 gm - 801412 Download Material Safety Data Sheet
PS-NH2 1.3 - 1.6 mmol/g (Click to download)		Scavenging acid chlorides, sulfonyl chlorides, isocyanates, and other electrophiles	3 gm - 800491 10 gm - 800263 25 gm - 800264 100 gm - 800265 1000 gm - 800307 Download Material Safety Data Sheet
PS-Thiophenol 1.0 - 1.5 mmol/g (Click to download)		Scavenging alkylating agents	3 gm - 800500 10 gm - 800273 25 gm - 800274 100 gm - 800275 1000 gm - 800310 Download Material Safety Data Sheet
NEW and Improved! MP-TMT 0.9 mmol/g (Click to download)		Scavenging palladium from aqueous and non-aqueous solutions	3 gm - 801506 10 gm - 801469 25 gm - 801470 100 gm - 801471 1000 gm - 801472 Download Material Safety Data Sheet
PS-Triphenylphosphine 2.2 mmol/g (Click to download)		Chlorination of acids and alcohols, Wittig and Mitsunobu reactions, scavenging of alkyl halides	3 gm - 800510 10 gm - 800378 25 gm - 800379 100 gm - 800380 1000 gm - 800381 Download Material Safety Data Sheet
PS-Trisamine 3.0 - 5.0 mmol/g (Click to download)		Scavenging acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles	3 gm - 800501 10 gm - 800228 25 gm - 800229 100 gm - 800230 1000 gm - 800309 Download Material Safety Data Sheet
NEW and Improved! MP-Trisamine 2.0 - 3.0 mmol/g (Click to download)		Scavenging acid chlorides, sulfonyl chlorides, isocyanates, and other electrophiles	3 gm - 801505 10 gm - 801397 25 gm - 801398 100 gm - 801399 1000 gm - 801400 Download Material Safety Data Sheet
PS-TsCl (High-Loading) 2.0 - 3.0 mmol/g (Click to download)		Scavenging of alcohols, amines and other nucelophiles	3 gm - 800490 10 gm - 800364 25 gm - 800365 100 gm - 800366 1000 gm - 800367 Download Material Safety Data Sheet
PS-TsNHNH2 1.8 - 3.2 mmol/g (Click to download)		Scavenging aldehydes and ketones	3 gm - 800497 10 gm - 800270 25 gm - 800271 100 gm - 800272 1000 gm - 800317 Download Material Safety Data Sheet
Polymer-Bound Reagents	Structure	Applications	Part Numbers
MP-Borohydride 2.5 - 3.5 mmol/g (Click to download)		Reduction of carbonyl compounds, azides and oximes; reductive amination; reduction of conjugated enones to unsaturated alcohols	3 gm - 800512 10 gm - 800401 25 gm - 800402 100 gm - 800403 1000 gm - 800404 Download Material Safety Data Sheet
PS-Carbodiimide 1.0 - 1.5 mmol/g (Click to download)		Coupling agent for amide and ester synthesis, pentafluoro-phenyl, other activated ester formation	3 gm - 800508 10 gm - 800369 25 gm - 800370 100 gm - 800371 1000 gm - 800372 Download Material Safety Data Sheet
MP-Carbonate 2.5 - 3.5 mmol/g (Click to download)		General base. Neutralizes ammonium salts, scavenges acids, acidic phenols	3 gm - 800493 10 gm - 800267 25 gm - 800268 100 gm - 800269 1000 gm - 800314 Download Material Safety Data Sheet
MP-Cyanoborohydride 2.0 - 3.0 mmol/g (Click to download)		Reductive amination; reductive methylation of primary and secondary amines, reduction of amines; reduction of conjugated enones to unsaturated alcohols	3 gm - 800511 10 gm - 800405 25 gm - 800406 100 gm - 800407 1000 gm - 800408 Download Material Safety Data Sheet
PS-DES 1.0 - 1.6 mmol/g (Click to download)		Linker for alcohols, carbonyl groups, acetylenes and aromatic compounds	3 gm - 800507 10 gm - 800142 25 gm - 800143 100 gm - 800144 Download Material Safety Data Sheet
PS-DIEA 3.0 - 4.0 mmol/g (Click to download)		Tertiary amine base	3 gm - 800494 10 gm - 800279 25 gm - 800280 100 gm - 800281 1000 gm - 800312 Download Material Safety Data Sheet
PS-DMAP 1.1 - 1.8 mmol/g (Click to download)		Catalyst for acylation reactions, "Catch and Release" applications	3 gm - 800492 10 gm - 800288 25 gm - 800289 100 gm - 800290 1000 gm - 800313 Download Material Safety Data Sheet
PS-HOBt(HL) 0.9 - 1.4 mmol/g (Click to download)		Active ester reagent; coupling of acids and amines; protecting group (Fmoc, Cbz, Boc) transfer	3 gm - 800509 10 gm - 800417 25 gm - 800418 100 gm - 800419 1000 gm - 800420 Download Material Safety Data Sheet
PS-NMM 1.5 - 2.5 mmol/g (Click to download)		Tertiary amine base	3 gm - 800496 10 gm - 800282 25 gm - 800283 100 gm - 800284 1000 gm - 800318 Download Material Safety Data Sheet
PS-PPh3-Pd (Click to download)		Catalyst for Suzuki reaction, other reactions catalyzed by Pd(Ph3-Pd)4	1 gm – 800473 10 gm – 800474 25 gm – 800475 NEW! 100 gm - 800476 Download Material Safety Data Sheet
PS-TBD 1.2 - 1.9 mmol/g (Click to download)		Alkylation of phenols and amines; esterification of carboxylic acids using alkyl halides; alkylation of activate methylene compounds; dehalogenation of organic halides; high throughput synthesis of aryl triflates and aryl nonaflates; Williamson ether synthesis	3 gm - 800513 10 gm - 800421 25 gm - 800422 100 gm - 800423 1000 gm - 800424 Download Material Safety Data Sheet
MP-Triacetoxyborohydride 1.8 - 2.4 mmol/g (Click to download)		Reductive amination with primary and secondary amines.	3 gm - 800517 10 gm - 800413 25 gm - 800414 100 gm - 800415 1000 gm - 800416 Download Material Safety Data Sheet
PS-Triphenylphosphine 2.2 mmol/g (Click to download)		Chlorination of acids and alcohols, Wittig and Mitsunobu reactions, scavenging of alkyl halides	3 gm - 800510 10 gm - 800378 25 gm - 800379 100 gm - 800380 1000 gm - 800381 Download Material Safety Data Sheet
PS-TsCl 1.0 - 2.0 mmol/g (Click to download)		Loading of alcohols followed by nucleophilic displacement ("Catch and Release"), scavenging of nucleophiles	3 gm - 800490 10 gm - 800276 25 gm - 800277 100 gm - 800278 1000 gm - 800316 Download Material Safety Data Sheet
MP-TsOH 3.5 - 4.5 mmol/g (Click to download)		Scavenging and "Catch and Release" of amines, acid catalysis	3 gm - 800498 10 gm - 800461 25 gm - 800462 100 gm - 800463 1000 gm - 800464 Download Material Safety Data Sheet
MP-TsOH(65) 3.0 mmol/g (Click to download)		Scavenging and "Catch and Release" of amines, acid catalysis	3 gm - 800499 10 gm - 800478 25 gm - 800479 100 gm - 800480 1000 gm - 800481 Download Material Safety Data Sheet
MP-TsOH Cartridge 2.5 mmol/g (Click to download)		"Catch and Release" amine purification, scavenging basic impurities, purification of compounds with basic sites.	0.5 gm resin in 6 mL cartridge, 30 per pack 800477-C30 Download Material Safety Data Sheet
MP-TsO-TEMPO 1.0 mmol/g (Click to download)		Oxidation of activated primary and secondary alcohols to the respective aldehydes and ketones.	3 gm - 800518 10 gm - 800482 25 gm - 800483 100 gm - 800484 1000 gm - 800485 Download Material Safety Data Sheet
ACTU Preparation of PS-HOBt(HL) (Click to download)		active esters; coupling of acids and amines	3 gm - 800516 10 gm - 800465 25 gm - 800466 100 gm - 800467 1000 gm - 800468

PS-Resine gel a basso polistirene cross-linking. I polistirene a basso Cross-linking richiedono tipicamente l’uso di solventi che rigonfiano la resine in modo da permettere ai reagenti di accedere ai gruppi funzionali delle resine supportate . Nei casi in cui i solventi non rigonfiano le resine, può essere necessario aggiungere un co-solvente che è compatibile con le resine, ad esempio il THF.

MP-Resine macroporose polistirene ad alto cross-linking. Le resine macroporose ad alto cross-linking si rigonfiano significativamente molto meno nel solvente rispetto alle PS e ai reagenti e non dipendono dal rigonfiamento per essere efficaci, diversamente dalle loro amologhe PS. Invece i reagenti si diffondono attraverso la struttura porosa per raggiungere i siti reattivi. Per questo motivo, le resine MP possono essere utilizzate in volumi confinati dove il rigonfiamento sarebbe un problema e possono essere utilizzate con un ampia varietà di solventi

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