Interim report January - June 2010
Biotage AB (publ) - disclosure notice of substantial holding of shares
Biotage appoints Anders Wikström as Vice President of Operations and Anthony Rees as Chief Scientific Officer
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Biotage are Gold Sponsors.
5th - 9th September
Copenhagen, Denmark21st - 24th September
Basel, SwitzerlandAugust 27-28
Orlando, FL10th - 12th November
Montreux, Switzerland1st - 3rd December
Barcelona, Spain
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Biotage Advancer Kilobatch™
Sequential Batch Microwave Synthesizer
Advancer Kilobatch provides up to 12 hours unattended processing of homogenous reaction mixtures delivering kilogram quantities of your target compound. In addition, the system will accommodate heterogeneous reactions by processing four sequential cycles (250 mL) to yield a 1 L batch. Through simple solid loading replenishment, kilogram quantities of complex heterogeneous reactions are easily achieved.
Scalability
Advancer Kilobatch is the only system for kilogram scale-up of all microwave reactions. Chemistry can be directly scaled up from the Initiator platform using exactly the same reaction conditions.
| The Advancer Kilobatch is specifically designed so that methods developed in Biotage lab-scale systems can be safely and predictably transferred to a larger scale without re-optimization. |
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Hetero- and Homogeneous Reactions
The Advancer Kilobatch supports both homogeneous reactions and the use of solid reagents, catalysts and crystallizing products found in heterogenous reactions.
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Solid loading
The solid loading mechanism of the Advancer Kilobatch allows four cycles of solid loads for every reaction batch. All solid chemicals are kept under inert atmosphere during these runs to insure cycle-to-cycle reproducibility. |
Flash (adiabatic) cooling evacuation
Adiabatic cooling rapidly evacuates the pressurized reaction vessel after each synthesis cycle. This flash cooling technique quickly quenches the reaction for better control sending the actively cooled reaction to the collection vessel and avoids the use of problem prone pumping of solutions.
Reproducibility
Exact temperature and pressure measurement, solid and liquid loading along with powerful stirring, and inert atmosphere conditions ensure reproducible results from cycle-to-cycle. Experimental data proves scale-up reproducibility from the Initiator gram-scale for each cycle within a batch and for consecutive batches.
Safety
A five-tiered safety system incorporates software and hardware interlocks, relief valves, pressure calibrated rupture disc and spring loaded cavity lid. The Advancer is completely self-contained protecting the end-user from any exposure.
Reliability
Designed and built according to Swedish quality standards, each component is verified and validated in a thorough testing program to ensure highest possible reliability.
Ease of use
The Advancer Kilobatch software is intuitively easy to operate and the hardware requires minimal interaction. Operation can be learned in minutes.
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System Specifications
Dimensions (W x D x H)
Weight
Power supply
Power consumption
Operating condition
Inbuilt computer
Performance
Reaction vessel
Reaction volume
Reaction temperature
Reaction heating
Reaction preasure
Power reange
Overhead stirrer
Solid reagent addition
Cooling
Connections
Water supply (cooling)
Pressurized Air (cooling)
Ventilation
Inert gas N2 (optional)
Entery port connection |
140x65x185 cm (55x26x73 inch)
~600Kg (1200 lbs)
Europe: 220 - 240 V~, 50 Hz (5 A)
US: 200 - 215 V~, 60 Hz (10 A)
3000 VA
18-32 °C & 20-95%RH (64-90 F)
Windows XP® based software,
17" Flatscreen, Mouse & Keybord, USB and
Ethernet port, Printer (optional, LAN or
USB), Advancer Software ver. 2.0
350 mL (Teflon®)
300 mL/single run
4 x 250 mL using solid dispensing
99 x 250 mL using only liquid dispensing
(requires external collection vessel)
60-250 °C
0.5-4 °C/sec
1-22 bar
0-1200 W
0-1100 rpm
4 compartments (0.5 - 90 g)
Instant Adiabatic Flash Cooling™, jacketed cooling collection vessel
3 L/min
60 L/min (5-10bar)
2.8 m3/min
2 x standard Upchurch Scientific® HPLC, 1/4 - 28
1 x Swagelok®, 6 mm
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Ordering information
Systems
Part Number
ADV1-0A
ADV1-0B
ADV1-1A
ADV1-1B |
Description
Advancer 350, base system
Advancer 350, base system
Advancer KiloBatch, sequential system
Advancer KiloBatch, sequential system |
Country/Certification
EU/CE, JP
US/UL/CSA, JP
EU/CE, JP
US/UL/CSA, JP
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Accessories
Part Number
360397
360414
360280
360286
361672 |
Description
Collection Vessel for adiabatic cooling, 350 mL
Stirrer, PEEK, Qty 2
Advancer standard 350 mL reaction vessel, Teflon®
Temperature probe pocket, Qty 2
Solids loading carosel |
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Print page
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