Interim report January - June 2010
Biotage AB (publ) - disclosure notice of substantial holding of shares
Biotage appoints Anders Wikström as Vice President of Operations and Anthony Rees as Chief Scientific Officer
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Biotage are Gold Sponsors.
5th - 9th September
Copenhagen, Denmark21st - 24th September
Basel, SwitzerlandAugust 27-28
Orlando, FL10th - 12th November
Montreux, Switzerland1st - 3rd December
Barcelona, Spain
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Isolera™ Flash Purification System
Intelligent features enable better separations in less time with fewer resources.
High performance flash chromatography at its best. |
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Unique Features: • Quatro-binary Gradient- can use 4 solvents in a single binary gradient
• Patented TLC to gradient optimizes sample load
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New: Detector Options • ELSD • UV-VIS |
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New: Gradient Optimization Save up to 60% on solvent costs - Learn more
Reduce solvent use up to 60% compared to traditional linear gradient elution potentially reducing your annual consumables or solvent expenses by thousands.
The Gradient Optimization "GO" feature converts a linear gradient into a step gradient, optimizing elution conditions around a user-identified eluting peak. Simply purify your sample in a small cartridge, e.g. a 50 g SNAP cartridge. Once the run is completed, select the Optimize button then select the peak of choice and a new method is created with an optimized Step Gradient. Just select the new cartridge and collection rack and the method self-adjusts to the new cartridge volumes and is ready to run. |
Isolera™, a new more compact flash purification system with intelligent features, enables chemists to easily achieve better separations. The advanced TLC-to-gradient feature automatically creates elution gradients and suggests cartridge and sample size. Collect fractions using two wavelengths, adjust the flow rate from 1 to 200 mL/min as needed and use up to four solvents in a single gradient, for maximum purity and yield.
Isolera is available in a single cartridge base model, the Isolera One, and a 4-cartridge configuration, the Isolera Four, which is ideal for multi-user or high-throughput laboratories.
Faster Flow Rates – increase productivity and save valuable time
With a flow range of 1 to 200 mL/min, Isolera dramatically shortens purification run-times. For example, a 10.5 g sample was purified at 200 mL/min on a 340 g Biotage SNAP cartridge in less than 19 minutes, see figure 1. If this same separation had been performed using a typical flash system with a 100 mL/min flow rate limitation, the purification would have taken twice as long.

Figure 1. The value of fast flow rates can be seen in the 10.5 gram purification at 200 mL/min using a SNAP 340g KP-SIL cartridge on an Isolera One. The total run time is 18.8 minutes.
Collect on 2 separate wavelengths – Recover more compounds
Collect eluting compounds that don’t absorb at the primary wavelength using the variable wavelength or UV-VIS diode array detector options. Instead of fractionating on a single wavelength while monitoring a second, Isolera can fractionate simultaneous on two unique user-defined wavelengths. This capability enables chemists to recover more of the compounds and get cleaner fractions, as highlighted in figure 2.

Figure 2. Fractionation using two wavelengths ensures collection of UV absorbing compounds at both wavelengths without sacrificing valuable fraction collection capacity in a “collect all” mode.
Additional features:
• Largest integrated fraction capacity • Quatro-binary Gradient – Use up to four solvents in a single gradient • Isocratic co-solvent – increase compound solubility and recovery • Default Methods – simplify method creation • On-the-fly editing – modify purification runs in progress • SNAP cartridges – increase loading capacity and improve compound separations. • Add an auxiliary detector – Use other detectors • An assortment of SNAP cartridges is included with the Isolera system • Connect an external auxiliary detector (refractive index or ELSD)

Specifications
Solvent delivery
Flow rate
Pressure limit
UV Detection
Flow cell path length
UV collection modes
Fractionation modes
Collection vessels
Power
System control & data management
Dimensions (W x H x D)
Weight
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Two constant volume (3-mL) electric HPFC pumps
1 – 200 mL/min
145 psi (10 bar)
Choice of variable dual-wavelength (200 – 400 nm), diode array detector (DAD), fixed (254 nm) detector, or UV-VIS (200-800nm)
0.3 mm
Single wavelength Dual wavelengths (variable UV and UV-VIS)
Volume, threshold, threshold with volume, low slope, medium slope, custom slope
Test tubes (13, 16, 18, and 25 mm) and bottles (120 mL, 240 mL, and 480 mL)
100 – 240 VAC, 50/60 Hz, 4.0 A
On-board computer with 10.4” diagonal touch-screen interface
355 mm (14”) x 596 mm (23.5”) x 497 mm (19.6”) (single bed) 565 mm (22”) x 596 mm (23.5”) x 497 mm (19.6”) (expanded bed)
30-35 kg (66-77 lb) |
Ordering information
The Isolera and Isolera Four systems are available in eight different configurations:
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Part Number ISO-1SF
ISO-1SV
ISO-1SW
ISO-1EF
ISO-1EV
ISO-1EW
ISO-4SF
ISO-4SV
ISO-4SW
ISO-4EF
ISO-4EV
ISO-4EW |
Description
Isolera One with fixed 254 nm wavelength detector and single fraction collector bed
Isolera One with variable 200-400 nm wavelength detector and single fraction collector bed
Isolera One with UV-VIS 200-800 nm wavelength detector and single fraction collector bed
Isolera One with fixed 254 nm wavelength detector and expanded fraction collector bed
Isolera One with variable 200-400 nm wavelength detector and expanded fraction collector bed
Isolera One with UV-VIS 200-800 nm wavelength detector and expanded fraction collector bed
Isolera Four with fixed 254 nm wavelength detector and single fraction collector bed
Isolera Four with variable 200-400 nm wavelength detector and single fraction collector bed
Isolera Four with UV-VIS 200-800 nm wavelength detector and single fraction collector bed
Isolera Four with fixed 254 nm wavelength detector and expanded fraction collector bed
Isolera Four with variable 200-400 nm wavelength detector and expanded fraction collector bed
Isolera Four with UV-VIS 200-800 nm wavelength detector and expanded fraction collector bed |
Accessories
Part Number 412019 412062 411789 411790 411791 411792 411793 411794 411934 411935 411926 FIV-VLV-1000 411081 |
Description Leak Detector System Standard Bed Leak Detector System Extended Bed Test tube rack, 13 x 100 mm, 4/pk Test tube rack, 16 x 100 mm, 4/pk Test tube rack, 16 x 150 mm, 4/pk Test tube rack, 18 x 150 mm, 4/pk Test tube rack, 25 x 150 mm, 4/pk Bottle rack, 120 mL, 4/pk Bottle rack, 240 mL, 1/pk Bottle rack, 480 mL, 1/pk Expanded bed upgrade Injection valve Injection valve to SNAP cartridge adapter |
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