Part No: P071Issued year: 2014File size: 0.35mbFile type: pdf
This poster demonstrates a simplified protocol for the simultaneous extraction of nicotine and its major metabolites including cotinine, nornicotine, 3-OH-cotinine, norcotinine and anabasine in plasma, urine, serum and whole blood using supported liquid extraction (SLE) followed by UPLC-MS/MS analysis.
Part No: AN051Issued year: 2010File size: 0.23mbFile type: pdf
A major cost for synthetic chemistry laboratories is solvent, especially solvent used for compound purification. Much of the wasted solvent lies in the space between peaks as seen in figure 1. As companies look to decrease operating costs, this expense is being targeted and ways to reduce expenditures sought.
Part No: AN058Issued year: 2012File size: 0.21mbFile type: pdf
The formation of diarylamines by reacting anilines with aromatic electrophiles is, usually, a reaction demanding long reaction
times, high temperatures and strong bases, in order to obtain acceptable yield, due to the low nucleophilicity of anilines.1 The Buchwald-Hartwig cross-coupling reaction is a very useable and elegant solution to this problem.2,3,4 Anticipating the classical metal-free SNAr-amination reaction, without using Pd-catalysts and strong bases, with only higher temperature and pressure as tool as depicted in the Scheme below,1 gives no product at all at 180 ºC and very low conversion (9 %) at 220 ºC for 15 minutes when heating by microwaves.5 Remainder was unreacted starting material.
Part No: AN903Issued year: 2007File size: 0.1mbFile type: pdf
A one-pot process for the preparation of Acyclovir from guanine is described. The key step involves a trimethylsilyl triflate (TfOTMS)-catalysed reaction of silylated guanine with 1,3-dioxalane under microwave irradiation. With this method, the yield is in the same range as with conventional heating, but the speed of the reaction is increased by a factor of 85.
Part No: P161Issued year: 2017File size: 0.76mbFile type: pdf
Hair is a useful matrix for drug analysis, as it can be used to show historical drug use. Parent drugs are often present in high concentrations, and the matrix is stable over time.
This poster describes the use of the Biotage® Lysera to pulverise and extract hair samples, with ISOLUTE® SLE+ supported liquid extraction columns to clean up the samples prior to analysis. Limits of quantitation set by the Society of Hair Testing for amphetamines are achievable with the described method (0.2 ng/mg).
SoHT 2017, Cardiff UK
Part No: PPS428Issued year: 2016File size: 0.85mbFile type: pdf
This technical note describes the use of layered SPE columns in applications where multiple suites of analytes with a broad polarity range are to be extracted simultaneously from a single water sample, such as organochlorine, triazine and organophosphate pesticides, or endocrine disrupters.
Part No: P141Issued year: 2016File size: 0.33mbFile type: pdf
For those chemists performing organic synthesis, reaction mixture purification by flash column chromatography is an integral and necessary part of the synthesis process. However, flash chromatography consumes large volumes of solvent which either needs to be recycled or disposed.
Part No: P130Issued year: 2015File size: 0.48mbFile type: pdf
The results from this research show that the chromatographic purification of organic amine compounds can be improved simply by using an amine-functionalized silica and typical normal-phase solvents such as hexane and ethyl acetate.
Part No: PPS418Issued year: 2016File size: 5.52mbFile type: pdf
Biotage has developed tools for every
step of the organic process, with the entire workflow in mind.
This dedicated suite of products vastly expands the
range of options in order to truly accelerate discoveries
of new molecules for future innovations.
Part No: CM-PAL-0810Issued year: 2010File size: 0.29mbFile type: pdf
PAL-ChemMatrix is highly recommended for microwave synthesis.
Under microwave heating conditions, such as Biotage Initiator
the PAL-ChemMatrix provides higher purity peptides than the
Rink Amide ChemMatrix. For manual synthesis or non-microwave
synthesis, we recommend using the Rink Amide ChemMatrix
Part No: AN099Issued year: 2015File size: 0.36mbFile type: pdf
A series of eight 3-alkylidylindolin-2-ones were conveniently synthesized on Biotage® Endeavor™ in high yield and purity. Reactor purging, agitation, pressurization, heating, gas uptake and run termination were performed automatically based on the run program.
Biotage has developed a range
of tools to improve the peptide synthesis workflow,
from synthesis of crude peptides through to the final
purified product. These solutions make your workflow
more efficient and improve the quality of peptides
you synthesize. Our workflow solutions are used in
pharma, biotech, CRO and academic laboratories
throughout the world.
Part No: PPS439Issued year: 2017File size: 0.7mbFile type: pdf
Dr. Andrew Jamieson leads a team of peptide chemists at the University of Glasgow, where
they synthesize complex molecules for chemical biology applications. An important tool that
contributes to their success has been Biotage® Initiator+ Alstra™ microwave peptide synthesizer,
and they are even breaking the dogma that only HPLC can be used for peptide purification, by
using cutting edge reversed phase flash purification techniques provided by Biotage.
Part No: I-Prime_ZIP_TN-30.1011Issued year: 2011File size: 0.3mbFile type: pdf
Biotage ZIP flash chromatography cartridges are engineered to meet the needs of chemists requiring high performance and consistency from a purification cartridge at a value price to reduce purification costs.
Isolera Prime flash purification system.