Part No: AN111Issued year: 2015File size: 1.19mbFile type: pdf
The cyclic peptide mupain-1 (CPAYSRYLDC) is an inhibitor of the cancer-related urokinase-type plasminogen activator. Here we show the synthesis of a non-natural arginine building block precursor using MAOS.
Part No: AN110Issued year: 2015File size: 0.72mbFile type: pdf
PNA oligomers have interesting properties such as their increased thermal and chemical stability and resistance to enzymatic degradation which drives their use in various molecular biology, molecular diagnostic, microarray, biosensor and antisense applications. In this study we synthesize two PNA oligomers on a small scale using the Biotage® Initiator+ Alstra™ microwave peptide synthesizer.
Part No: Issued year: 2004File size: 0.09mbFile type: pdf
Solid-Assisted Solution Phase Synthesis (SASPS) is a technique where the target molecule is synthesized in solution and solid-supported molecules are used as reagents, catalysts or scavengers. Recently this technique has been getting a lot of attention as an alternative to solid phase organic synthesis (SPOS), since it offers many of the advantages of SPOS in terms of ease of reaction workup and product purification in addition to the advantages associated with traditional solution-phase chemistry (e.g. the ease of monitoring the progress of the reaction by simply applying LC-MS or TLC techniques).
Part No: P043Issued year: File size: 0.31mbFile type: pdf
The application of microwave irradiation in solid
phase peptide synthesis (SPPS), is an important tool
for the synthesis of difficult and long peptide
sequences that are often obtained in poor quality by
comparable conventional methods at room
temperature. Here we present the results obtained
for the synthesis of a number of difficult peptide
sequences using different levels of automation for
microwave assisted SPPS: manual, semi-automated
and fully automated systems. Syro wave, initiator, sp wave
Part No: PPS449Issued year: 2017File size: 0.61mbFile type: pdf
Migrate from mg to g Without Reoptimization. Biotage high precision reaction vials are engineered for durability and safe reactions. All vials withstand 30 bar pressures in a wide range of conditions. Designed for use with Biotage® Initiator+ and Initiator microwave synthesizers.
Speeding up reactions has never been easier. Biotage microwave
synthesizers are the first-choice tools for organic chemists who
need to accelerate their production of new compounds.
Initiator, Initiator+, robot, vials, phase separator, work up tools
Part No: SS-INT.R 0611Issued year: 2011File size: 1.28mbFile type: pdf
The 60-position sample bed supports the production of focused libraries, multi-user environments and scale-out. Flexible operation enables the use of both large and small vials in combination at any time and in any order without manual intervention.
Part No: Issued year: File size: 0.18mbFile type: pdf
Solid-phase synthesis combined with fast and
precise heating by microwave irradiation has
become a valuable tool for peptide chemists. It
enables easier solid-phase assembly of difficult
peptide sequences and even small proteins. Here
we present, a study of microwave assisted solidphase
peptide synthesis using different resins on
the Syro WaveTM. Furthermore, we use this
methodology to synthesize difficult peptide
sequences including a multiple display
Part No: Issued year: File size: 0.45mbFile type: pdf
This paper evaluates solvent effect upon flash chromatography purification. The impact of sample mass overloading, volume overloading and sample dissolution solvents upon sample resolution are discussed.
Part No: TN0021.0707Issued year: 2007File size: 0.36mbFile type: pdf
MP-Borohydride is a macroporous, resinbound borohydride that is a resin bound equivalent of tetraalkylammonium borohydride. The bound borohydride is a versatile reducing agent1,2,3 used for the reduction of carbonyl compounds and imines, and the reductive amination of aldehydes and ketones (Scheme 1). While the free form reagent is generally used in large excess and requires extraction of the reaction mixture for workup, the resin bound form can be used in slight excess and removed easily via filtration of the resin. The resin is compatible with microwave heating, which reduces the reaction time from hours to minutes4.
Part No: TN509Issued year: 2003File size: 0.12mbFile type: pdf
MP-TsO-TEMPO is a macroporous polystyrene-bound equivalent of oxoammonium p-toluenesulfonate. The
resin has primary applications in the oxidation of activated primary and secondary alcohols to their
corresponding aldehydes and ketones under mild reaction conditions.MP-TsO-TEMPO has been found to be
highly selective for oxidation of allylic, benzylic and alicyclic hydroxy compounds.Oxidations with
MP-TsO-TEMPO are very clean and the product is isolated by filtration of the resin followed by solvent removal.
Part No: TN506Issued year: 2004File size: 0.07mbFile type: pdf
MP-TsOH(65) columns have been designed specifically for isolation and purification of amines. The columns may also be used to scavenge basic reagents, substrates and reaction byproducts. A range of configurations is available from 100 mg/3 mL to 2.5 g/25 mL, including tab-less 3 and 6 mL for 48 and 24- well applications respectively. See page 6 for ordering information.