Part No: P077Issued year: 2014File size: 0.48mbFile type: pdf
This poster uses gel electrophoresis data to visually illustrate the amount of residual protein in extracts prepared using protein precipitation, supported liquid extraction and various silica and polymer based SPE approaches.
Part No: TN125Issued year: 2003File size: 0.07mbFile type: pdf
The ISOLUTE HCX series of mixed-mode SPE sorbents is based on a combination of strong cation exchange and non-polar chemistries. Basic drugs are retained by two primary retention mechanisms. This allows a rigorous interference elution regime to be used to elute interferences retained by either non-polar or cation exchange interactions alone. Only analytes with both non-polar and basic characteristics are extracted using the ISOLUTE HCX series of sorbents, providing an extremely pure final extract.
Part No: TN126Issued year: 2003File size: 0.06mbFile type: pdf
ISOLUTE non-polar SPE sorbents retain drugs from aqueous biological fluids through hydrophobic interactions. Endogenous compounds from the original sample matrix, such as proteins, are not retained. When the sorbent is rinsed, weakly retained compounds are eluted to waste, leaving strongly retained compounds to be eluted in the final elution solvent.
Part No: Issued year: 2007File size: 0.48mbFile type: pdf
•Extends the range of acidic, basic and neutral compounds that can be extracted using a single generic method, increasing method development productivity•Has an optimized pore structure which reduces the extraction of endogenous matrix components, and leads to cleaner extracts that give fewer matrix effects in LC-MS/MS analysis•Has optimized physical and chemical characteristics that improve reliability of SPE procedures•Has no secondary interactions, allowing the use of pure organic elution solvent to give high recoveries of very low drug concentrations
Part No: TN127Issued year: 2003File size: 0.28mbFile type: pdf
ISOLUTE HAX mixed-mode SPE sorbent is based on a combination of strong anion exchange and non-polar chemistries. Acidic drugs are retained by two primary retention mechanisms. This allows a rigorous interference elution regime to be used to elute interferences retained by either non-polar or anion exchange interactions alone. Only analytes with both non-polar and acidic characteristics are extracted usign the ISOLUTE HAX sorbent, providing an extremely pure final extract.
Part No: Issued year: 2004File size: 0.31mbFile type: pdf
1.We have developeda general method for synthesizing Diaryl Ethers from both electron richand electron deficient phenols.
2.We have showedthat with our instrumentation we have removedscalabilityas alimiting factor for the ”bench” chemist.
3.We have also developeda new cooling technique on the Advancer that dramaticallyshortens coolingtimes. For ethanol: 180 ºC to 70 ºC within less than 10 seconds..
Part No: P020Issued year: 2008File size: 0.16mbFile type: pdf
The trend pharma industry is clearly to speed up the process from lead identification to selection of candidate drug. One of the major limitations is the availability of larger amounts typically hundreds of grams, of the potentially active substance to be further investigated
Part No: P012Issued year: 2006File size: 0.22mbFile type: pdf
The use of palladium-catalysts in the synthesis of fine chemicals, pharmaceutical intermediates and active pharmaceutical ingredients (APIs) has become quite common in the last few decades. The number of palladiumcatalyzed reactions (both achiral and chiral) available to chemists has provided access to more complex structures in fewer steps and with less waste. An unfortunate side effect of using palladium is the potential for palladiumcontaining impurities to remain in the desired compound after isolation. This is an especially significant problem for the pharmaceutical industry since there is a low limit for heavy metal impurities allowed in the drug substance.
Part No: AN072.v2Issued year: 2013File size: 0.39mbFile type: pdf
Here we present the separation capabilities of a new type of designed adsorbent, RENSA® Boronate. This new resin has affinity for diols and α-hydroxycarboxylic acids and is able to extract those target compounds with high efficiency and selectivity.
Part No: Issued year: 2010File size: 0.26mbFile type: pdf
• Solid-Phase Peptide Synthesis (SPPS) is still often
faced with difficulties in the assembly of long and
‘difficult’ sequences, e.g. due to aggregation and
steric hindrance giving rise to incomplete reactions.
These problems have only partly been solved by
new coupling reagents and solid supports.
• Precise microwave heating has emerged as one
new parameter for SPPS, in addition to coupling
reagents, resins, solvents etc.