Part No: Issued year: 2013File size: 2.08mbFile type: pdf
Amide-linked homopolymers of sialic acid offer the advantages of stable secondary structure and increased bioavailability making them useful constructs for pharmaceutical design and drug delivery. Defining the structural characteristics that give rise to secondary structure in aqueous solution is challenging in homopolymeric material due to spectral overlap in NMR spectra. Having previously developed computational tools for heteroologomers with resolved spectra, we now report that application of these methods in combination with circular dichroism, NH/ND NMR exchange rates and nOe data has enabled the structural determination of a neutral, d-amide-linked homopolymer of a sialic acid analogue called Neu2en.
Keywords: sialic acid; Neu2en; NMR; circular dichroism; helical peptide; water-soluble scaffold; blood serum; proteolysis; 1,3-dipolar cycloaddition chemistry; click chemistry; Initiator+ SP Wave
Jonel P. Saludes, Travis Q. Gregar, I. Abrrey Monreal, Brandan M. Cook, Lieza M. Danan-Leon, Jacquelyn Gervay-Hague
Part No: Issued year: 2007File size: 0.22mbFile type: pdf
Biotage has created a new Resin-based Chemistry Kit that contains a variety of resins
designed to enable a choice of key resin-assisted chemistries with optimized protocols
(Figure 1). Reductive amination, coupling (C-C or C-O bond formation), amide bond
formation and oxidation are widely used traditional chemical transformations you’ll be able
to perform with this new kit.
Part No: TN-0021.0207Issued year: 2007File size: 0.34mbFile type: pdf
Resins are usually described as one of 2 main types, Gel (PS) or macroporous (MP).
The gel resins have a low cross-linking and need to swell to allow access to their
functional groups. Therefore, they are very effective in transformations requiring
swelling organic aprotic solvents such as DCM, THF, Dioxane etc. Conversely, MP
resins are more highly cross-linked with more of a permanent open pore structure,
so they do not require swelling in such solvents for effective performance. As a
result, MP resins are compatible with a wider range of solvents than PS resins and
perform better in solvents such as water, MeOH and MeCN. Resins are generally
stable and can be stored indefinitely under cool dry conditions. For longer term
storage standard refrigeration (4 °C) is recommended.
Biotage offers the widest range of solvent evaporation systems available. This guide presents the most suitable evaporation system for your research requirements, and answers common questions regarding service, maintenance and applications.
Keywords: turbovap, turbo vap, v10, v-10, spedry, spe dry, evaporation, concentrat
Part No: AN037Issued year: 2001File size: 0.13mbFile type: pdf
Activated carbon is an adsorbent media used to remove colored compounds from solution. Using carbon in a packed bed, such as the Biotage FLASH-AC cartridge improves adsorbent performance. The key variable in optimizing the decolorization process is the solvent system. Varying the solvent system impacts the adsorbent capacity of the cartridge, affecting both the yield and purity of the product. Biotage FLASH-AC cartridges tolerate a wide range of process solvents. This note discusses solvent choice as a process variable and how it contributes to significant process improvement and reduces the total cost of operation.
Part No: IST1080Issued year: 2006File size: 0.1mbFile type: pdf
SPE Application for the Multiresidue Extraction and Clean Up from Fruit and Vegetables. The method can be used for the extraction of a range of commodities (fresh fruits and
vegetables) and is suitablefor analysis of organophosphorus, organochlorine and carbamate pesticide types, using a variety of appropriate analytical techniques.
Part No: IST1057AIssued year: 1999File size: 0.07mbFile type: pdf
The following method addresses the extraction of 6-monoacetyl morphine from urine using
non-polar and strong cation exchange retention mechanisms. This compound can confirm
heroine use since it is a heroine metabolite, but not a metabolite of codeine or morphine
Part No: IST1002AIssued year: 2011File size: 0.04mbFile type: pdf
This method has been optimized for the extraction of cocaine and benzoylecgonine from urine for drugs of abuse applications. Typical recoveries of these drugs are > 85%. The procedure may be applied to plasma, serum or whole blood with suitable modifications.
Cocaine, BZE, Benzoylecgonine, Biotage, ISOLUTE, HCX, Ion Exchange, drugs of abuse, drug testing,