Part No: Issued year: 2011File size: 0.23mbFile type: pdf
• Biologically active peptides isolated from natural sources, e.g. marine sponges, often contain multiple N-methylated residues. Additionally, Nmethylation of synthetic peptides can improve pharmacokinetic properties like bio-availability and stability.
Part No: TV-SS-02Issued year: 2010File size: 0.1mbFile type: pdf
The TurboVap II sensor is designed to monitor the concentration process. It does this with light and logic. The sample tube stem sits in a light beam at about 0.8mL for 1mL tubes and at 0.5mL for the 0.5mL tubes. Every second, a microprocessor receives an indication of the change in optical density of the solution being concentrated. Small changes in optical density over a thirty second period are registered to memory and become the new initial or zero point for the sensor to look at the next change. When the sample is done and the meniscus crosses the sensor beam, a large change in optical density takes place and the TurboVap II beeps. The change for either dark or clear must persist for several seconds for the sensor to beep. At this point the gas flow stops and an alarm sounds to indicate that the sample is complete. When the attendant looks at the control panel, a blinking light indicates which position is complete.
Part No: Issued year: 2006File size: 0.09mbFile type: pdf
Why Use MAOS?
• Accelerated reaction kinetics
• Increased conversion of starting materials to products
• Reaction mixtures are often cleaner than conventional synthesis
• Small to large scalability
• Auto-sampler allows for overnight runs
• Extremely easy to operate
Part No: Issued year: 2010File size: 1.9mbFile type: pdf
User Report: V-10, Sumitomo Dainippon Pharma. Sumitomo Dainippon Pharma is recognized worldwide for its highly creative drug discovery program for treating neuropsychiatric disorders, and in specialized areas with high unmet medical needs. Its Genomic Science Laboratories installed the V-10 evaporation system in 2008, which has been used extensively for drying in-house compounds. We asked two researchers at that facility, Mr. Masahiko Ikeda and Mr. Fumitaka Nishino, about their use of the V-10 in their daily work.
Part No: Issued year: 2005File size: 0.57mbFile type: pdf
Use of the unique opportunities of an academic environment for the synthesis of high-quality libraries of diverse chemical structures to discover small molecules with
architecturally novel scaffolds and a wide range of physicochemical properties and to develop innovative new methodologies for Diversity-Oriented Organic Synthesis
Part No: TN115Issued year: 2006File size: 0.08mbFile type: pdf
This Chemistry Data Sheet describes the use of ISOLUTE® HM-N as a support material for pre-absorption of a
reaction mixture prior to flash chromatography. This approach is used as a solution to loading reaction
mixtures that are only soluble in polar solvents onto an ISOLUTE Flash SI II or Flash NH2 column.
Part No: TN118Issued year: 2006File size: 0.07mbFile type: pdf
ISOLUTE HM-N is a modified form of diatomaceous earth that can efficiently absorb aqueous samples. ISOLUTE HM_N is chemically inert and stable in the pH range 1-13. These characteristics make it a versabile material that plays an important role in many sample preparation applications.
Part No: Issued year: 2006File size: 0.83mbFile type: pdf
• Novo Nordisk A/S & radiochemistry at Novo Nordisk A/S
• Introduction to radiochemistry in general
• Radiochemistry & microwaves
• Selected case stories from the labs at Novo Nordisk A/S
• Applications of radiolabelled compounds
• Summary and acknowledgements
Part No: P016Issued year: 2007File size: 0.16mbFile type: pdf
In order to obtain a fast synthesis of an N-unprotected tripeptide, microwave (mw) assisted deprotection, coupling and partial deprotection were applied starting with a purified protected dipeptide [Fig. 1]. The three consecutive mw assisted steps were performed without any intermediate purifications and were accomplished within some 30 minutes. The resulting crude mixture containing the Boc deprotected tripeptide ester was shown to be quite complex [Fig. 2]. The crude product was subjected to automated reversed phase flash chromatography, followed by automated fraction pooling and “thin film evaporation”. The total time for the entire procedure was 1 h 20 min. The purity of the product was > 99%.
Part No: PPS433Issued year: 2016File size: 0.78mbFile type: pdf
Customer Case: Japan Frozen Foods Inspection Corporation.
The Japan Frozen Foods Inspection Corporation (JFFIC) made the transition from traditional mouse
testing of shellfish toxins, to instrumental analysis by developing original methods. In the sample
preparation procedure JFFIC uses EVOLUTE® ABN hydrophilic/hydrophobic SPE columns from Biotage.