Part No: AN713Issued year: 2011File size: 0.09mbFile type: pdf
The following methods have been developed for the selective extraction of the tobacco specific nitrosamine, NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol) from aqueous sample matrices such as biological fluids (e.g., urine). The method is highly reproducible and offers NNAL recoveries in the range of 90% and a limit of detection below 5 ppt.
AFFINILUTE, MIP, Molecularly Imprinted Polymers, SupelMIP
Part No: AN884Issued year: 2017File size: 0.62mbFile type: pdf
TSNAs, or tobacco-specific nitrosamines, are carcinogens found in tobacco products, including e-cigarettes and smokeless tobacco. This proof of concept study focusses on NNN (n-nitrosonornicotine), but the supported liquid extraction methodology described is a also suitable for NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) and NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol).