Catalytic hydrogenation is one of the most broadly practiced synthetic transformations in organic synthesis, and the ability to readily execute multiple hydrogenations is a key tool in the synthetic chemist’s repertoire of parallel techniques. In this experiment, reduction of a series of 3-alkylidenylindolin-2-ones to 3-alkylindolin-2-ones was undertaken as a demonstration of the capability of Biotage® Endeavor™ for parallel hydrogenation.
Biotage® Endeavor™ is a proven parallel pressure reactor system that facilitates hydrogenation, gaseous reactions, and catalyst screening applications.
Scheme 1. Parallel catalytic hydrogenation of 3-alkylidenylindolin-2-ones at elevated pressure.
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