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Easier Cyclosporine Monitoring After Organ Transplant

13 January 2014

Following the transplant of a heart, liver, kidney or lung, patients must be regularly tested for cyclosporine during the rest of their lives. Cyclosporine is an immunosuppressant used in organ transplants to overcome rejection, and blood testing intervals vary from 1 to 6 months.

 

A rapid reference method is presented in this application, ideal for batch tests with the advantage of no metabolite interference which is always found in immunological methods. This application uses the RapidTrace® modular system for SPE sample preparation and TurboVap® LV for quick evaporation to dryness. 

This application was developed in collaboration with Dr. Sean Maguire of the Biochemistry Department at the Mater Misericordiae Hospital in Dublin, who helped produce this fast automated method of extracting and cleaning up of blood samples for Cyclosporine detection well below therapeutic levels.

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