Targeted methods are of little use among laboratories testing for drugs of abuse when new synthetic cannabinoids are constantly emerging. Scheidweiler et al. have developed an assay that is "...designed to be easily updated for the latest emerging NPS" (NPS=New Psychoactive Substance). "SLE recoveries were >76.2% for all metabolites and should accommodate new synthetic cannabinoids as new reference standards become available".
Nontargeted SWATH acquisition for identifying 47 synthetic cannabinoid metabolites in human urine by liquid chromatography-high-resolution tandem mass spectrometry Karl B. Scheidweiler, Michael J. Y. Jarvis, Marilyn A. Huestis »