Starting out with p-hydroxybenzaldehyde, a four step synthetic pathway led to the synthesis of a benzofuran derivative in high yield and purity using Biotage® Endeavor™ catalyst screening system. With eight parallel reaction chambers, one single run was sufficient to identify optimal catalyst and reaction conditions. The system also handled the final catalytic alkene hydrogenation step while monitoring pressure and temperatures.
Scheme 1. Synthesis of Benzofuranylmethyl-2,4-Thiazolidinediones.
New Application Note for Simultaneous Extraction of Aldosterone and Angiotensin I and II from Human Plasma
Get Rid of Peptide Cleavage Cocktail in Three Minutes
The Secret Behind Green Purification
Two New Application Notes for Extraction of 1-nor-9-Carboxy-Δ9-THC from Hydrolyzed Urine
Convert Your TurboVap® LV Into a TurboVap® II