A number of fluorinated and fluorine-free pyrazole derivatives were designed and synthesized by a Spanish-US research group to increase understanding of mitochondrial dysfunction, which plays a key role in drug development. The synthetic pathway involves synthesis of 1,3,5-substituted pyrazole precursors, and coupling with key aldehyde intermediates. All microwave reactions were carried out using Biotage microwave reaction vials and Initiator microwave synthesizer.
The outcome was a range of biologically active fluorinated and fluorine-free analogues of commercial acaricide tebufenpyrad.
Raquel Román, Antonio Navarro, Dariusz Wodka, Maria Alvim-Gaston, Saba Husain, Natalie Franklin, Antonio Simón-Fuentes, and Santos Fustero, 2014. Synthesis of Fluorinated and Nonfluorinated Tebufenpyrad Analogues for the Study of Anti-angiogenesis MOA. Org. Process Res. Dev., 2014, 18 (8), pp 1027–1036.
New Findings presented at ASMS 2018
Webinar: A Roadmap to Successful Flash Chromatography
Evaporate Water from Reaction Mixtures in Less Than 10 Minutes
Evaporation of Heat-sensitive Compounds
Quick and Easy Removal of High Boiling Solvents