For peptide acids, we recommend using the HMPB-ChemMatrix as this resin will provide high crude purity and a recovery yield of 90-95%. The Wang-ChemMatrix will produce similar crude peptide purity, but the recovery yield is lower (60-70%). On request, we can provide preloaded HMPB-ChemMatrix resins with all 20 naturally occurring amino acids. Other amino acids can be preloaded on special request.
Rink Amide ChemMatrix is one of the most popular resins for both manual solid phade peptide synthesis (SPPS) and automated SPPS, under microwave or non-microwave conditions.
Trityl-ChemMatrix is mainly used to obtain a protected peptide as is has very low TFA cleavage conditions (under 1%). This resin therefore has the same cleavage conditions as the Cl-Trityl-polystyrene. On request, Trityl-ChemMatrix resins can be offered preloaded will all 20 natural amino acids. Other amino acids can be preloaded on special request. Please take note that the Cl-Trityl-ChemMatrix resin is not offered for stability reasons. It is more effective to start with the Trityl-ChemMatrix resin, chlorinate the resin and then add the amino acid required.
Wang ChemMatrix was the first ChemMatrix resin developed for peptide acids. It remains to this day one of the work-horses for solid phase peptide synthesis (SPPS).