|Sample processor||Robot Eight/Robot Sixty|
|Processing capacity||8 vials/60 vials|
|Rack capacity (large)||2x2 vials/2x12 vials|
|Rack capacity (small)||2x4 vials/2x30 vials|
|Vial sizes||0.2–0.5; 0.5–2; 2–5; 10–20 mL|
|Operating temperature||18–32 °C|
|Storage temperature||-25 °C to 60 °C|
|Humidity||20–95% at room temperature|
|Electrical supply||Supplied by Initiator|
|Certifications||CE, CSA certified|
|Initiator+ Eight||28 kg (61.7 lbs)|
|Initiator+ Sixty||34 kg (75 lbs)|
|Initiator+ Eight||400 x 500 x 580 mm (15.7" x 19.7" x 22.8")|
|Initiator+ Sixty||625 x 422 x 470 mm (24.6" x 16.6" x 18.5")|
|Initiator Sixty||625 x 405 x 470 mm (24.6" x 15.9" x 18.5")|
The cyclic peptide mupain-1 (CPAYSRYLDC) is an inhibitor of the cancer-related urokinase-type plasminogen activator. Here we show the synthesis of a non-natural arginine building block precursor using MAOS.
Tags: Application Notes
The formation of diarylamines by reacting anilines with aromatic electrophiles is, usually, a reaction demanding long reaction
times, high temperatures and strong bases, in order to obtain acceptable yield, due to the low nucleophilicity of anilines.1 The Buchwald-Hartwig cross-coupling reaction is a very useable and elegant solution to this problem.2,3,4 Anticipating the classical metal-free SNAr-amination reaction, without using Pd-catalysts and strong bases, with only higher temperature and pressure as tool as depicted in the Scheme below,1 gives no product at all at 180 ºC and very low conversion (9 %) at 220 ºC for 15 minutes when heating by microwaves.5 Remainder was unreacted starting material.
Tags: Application Notes, English
Biotage has developed tools for every
step of the organic process, with the entire workflow in mind.
This dedicated suite of products vastly expands the
range of options in order to truly accelerate discoveries
of new molecules for future innovations.
Speeding up reactions has never been easier. Biotage microwave
synthesizers are the first-choice tools for organic chemists who
need to accelerate their production of new compounds.
Initiator, Initiator+, robot, vials, phase separator, work up tools
•Metal-mediated [2 + 3] cycloaddition to coordinated nitriles
-- synthesis of new transition metal complexes
-- synthesis of new heterocycles
-- enantioselective synthesis of heterocycles
role of microwaves?
• Platinum-catalysed cycloisomerisation of alkynes
-- Synthesis of Taxol-like compounds
-- highly efficient and atom economic chemistry
role of microwaves?
Tags: Manuals & User Guides
In order to obtain a fast synthesis of an N-unprotected tripeptide, microwave (mw) assisted deprotection, coupling and partial deprotection were applied starting with a purified protected dipeptide [Fig. 1]. The three consecutive mw assisted steps were performed without any intermediate purifications and were accomplished within some 30 minutes. The resulting crude mixture containing the Boc deprotected tripeptide ester was shown to be quite complex [Fig. 2]. The crude product was subjected to automated reversed phase flash chromatography, followed by automated fraction pooling and “thin film evaporation”. The total time for the entire procedure was 1 h 20 min. The purity of the product was > 99%.
For high efficiencyin parallel synthesisand method developement short reaction timesare essential. We have examinedthe possibilityof maintaining reported selectivitiesin rapid, high temperaturepalladium-catalyzed asymmetric allylic alkylations. Reactions were promotedby useof singlemode microwave heating(vide infra),which oppositeto conventional oilbath heating(wallheat transfer) rapidlyand almost homogeneouslyheat largeparts of the sample(internalheat transfer).
The 60-position sample bed supports the production of focused libraries, multi-user environments and scale-out. Flexible operation enables the use of both large and small vials in combination at any time and in any order without manual intervention.
Tags: Product Notes
Mr. Shigeru Yonekubo at Kissei Pharmaceutical Co., Ltd. is right at the center of advanced drug development. In this interview, he explains how his company benefits from flash purification sys...24 June 2015
Process up to 60 microwave reactions unattended on a Biotage® Initiator+ microwave synthesizer equipped with the Robot Sixty option. Automated microwave synthesis is ideal for method d...
This product was withdrawn on April 1st 2014.
Biotage® Initiator+ represents the latest in microwave synthesis performance. This instrument’s high-end specifications enable the chemist to explore new areas and perform the latest of innovations in chemistry. A reliable and upgradeable platform that allows chemists to make great discoveries in less time.
|Part No.||Description||Product type||Pack Size||Price|
|353478||Vial Rack (New) 0.2 - 5ml||Accessories||1||Log in for price|
|354798||Vial Rack 10-20 mL, Robot 60||Accessories||1||Log in for price|
|355380||Initiator Robot Eight||Accessories||1||Log in for price|
|355381||Robot Sixty||Accessories||1||Log in for price|
|355391||Vial Rack, 5ml Robot 8||Accessories||1||Log in for price|