
Biotage® MP-Trisamine is a macroporous polystyrene-bound scavenger, for electrophiles such as acid chlorides, sulfonyl chlorides, and isocyanates.
Part No. | Description | Product type | Pack Size | Price | ||
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801397 | Biotage® MP-Trisamine, 10 g | Consumables | 1 | Log in for price | |
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801398 | Biotage® MP-Trisamine, 25 g | Consumables | 1 | Log in for price | |
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801399 | Biotage® MP-Trisamine, 100 g | Consumables | 1 | Log in for price | |
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801400 | Biotage® MP-Trisamine, 1 kg | Consumables | 1 | Log in for price | |
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801505 | Biotage® MP-Trisamine, 3 g | Consumables | 1 | Log in for price |
Committed to preserving our shared environment – further details available on request.
Can be used in processes in compliance with cGMP standards.
Manufacture of consumables is accredited by the world renowned British Standards Institute.
Flexible supply chains, back up manufacturing and warehousing ensures supply risk reduction
Can be used in processes in compliance with GLP standards.
Products which are scaleable from lab or development to process scale.
Long to indefinite product shelf life, reduced process risk.
Supports pharma guidelines for reducing elemental impurities in APIs.
Further extractable information provided on request.
Raw materials certified free of materials of human or animal origin.
Chemical substances used in our manufacturing process do not require registration.
Able to withstand mechanical stirring and heating under normal reaction conditions.
Download the product note.
Biotage® MP-Trisamine is a macroporous polystyrene-bound scavenger, for electrophiles such as acid chlorides, sulfonyl chlorides, and isocyanates. Resin-bound scavengers are added after a reaction is complete in order to quench and react selectively with excess reactants and/or reaction by-products.
MP-Trisamine is a highly cross-linked, robust, and low-swelling material, which makes it ideal for restricted volume environments (e.g. microwave vials, 96-well plates, etc.). Its unique pore structure provides greater access to the reactive sites without the need for solvent swelling, resulting in faster reactions and higher recoveries. The abrasion-resistant matrix has better handling characteristics and reduced transfer losses.
Biotage supplies two bound Trisamines ligands. As well as MP-Trisamine, Biotage® Si-Trisamine is a powerful metal scavenger for transition metals such as Palladium, copper, zinc and iron. (see product note PPS372)
The scavenging capability of MP-Trisamine was tested with a series of five electrophiles, present at an initial concentration of 0.5 M in dichloroethane (Table 1).
Electrophile |
Resin |
Equivalents |
% Scavenged in 0.5 h |
4-chlorobenzoyl chloride |
PS-Trisamine |
3.5 |
100 |
MP-Trisamine |
3.5 |
100 |
|
2-phenylbutyryl chloride |
PS-Trisamine |
3.5 |
100 |
MP-Trisamine |
3.5 |
100 |
|
2,6-dimethoxybenzoyl chloride |
PS-Trisamine |
3.5 |
100 |
MP-Trisamine |
3.5 |
100 |
|
3-methoxyphenyl isocyanate |
PS-Trisamine |
3.0 |
92 |
MP-Trisamine |
3.0 |
100 |
|
Benzene sulfonyl chloride |
PS-Trisamine |
4 |
100 |
MP-Trisamine |
4 |
100 |
Under these conditions, four of the five electrophiles were scavenged within 0.5 h, using either of the two scavengers. The now defunct PS-Trisamine was unable to scavenge 3-methoxyphenyl isocyanate to completion in this time.