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    Documents | Extraction of Acidic, Neutral and Basic Drugs from Urine using ISOLUTE® HCX Columns

    Extraction of Acidic, Neutral and Basic Drugs from Urine using ISOLUTE® HCX Columns


    The method addresses the extraction of all three classes of drugs of abuse from urine using non-polar and cation exchange retention mechanisms on the ISOLUTE HCX mixed mode column. This protocol was optimized to eliminate the use of dichloromethane in the elution of the acidic / neutral drug fraction.

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