The extraction and segregation of Organic compounds from core samples taken from marine sediments is used to predict climate conditions, reconstruct sea temperatures and identify the type of vegetation from the C3 ( Temperate cli-mate) and C4 ( Tropical Climate) isotopic mass spectroscopy ratio analysis.

Application Notes

Polycyclic aromatic hydrocarbons (PAHs) can be found in a number of water types, such as drinking water, surface water, ground water and wastewater. There are serval types of extraction techniques that can be implemented to remove them from water for measurement including liquid-liquid extraction (LLE), continuous liquid-liquid extraction (CLLE) and solid phase extraction (SPE). With LLE and CLLE there is little selectivity within the methods for difficult matrices or other compound interferences.

5000 Application Notes Disk Drinking water English Environmental GC-MS Ground water PAHs Polyaromatic Hydrocarbons (PAH) Waste water

With the widespread clinical use of antidepressant drugs comes the need to accurately measure therapeutic lev-els to determine proper dosage, as well as check for toxic levels and patient compliance. More and more laboratories are shifting their therapeutic drug monitor-ing from liquid extraction to solid phase extraction. A large clinical laboratory has automated the process of extracting these drugs from serum using the RapidTrace SPE Workstation.

Application Notes

This study shows that the Biotage® 4790 Automated Extractor system, along with the Atlantic™ DVB disk, the DryDisk® separation membrane, and the DryVap® Concentrator System can be successfully used to analyze for Nonyl Phenol and Bisphenyl A in water samples. This sample preparation process is fully automated, requiring minimal human intervention, and allowing for reductions in sample processing costs.

5000 Application Notes Bisphenol A Disk Drinking water Endocrine disrupter English Environmental Environmental contaminants GC-MS Nonyl phenol Water

When analyzing human urine for drugs of abuse, one of the most common tests is for the cocaine metabolite Benzoylecgonine (BZE). A contract laboratory has automated this labor intensive procedure using the RapidTrace.

Application Notes Benzoylecgonine Column Drugs of Abuse Forensic GC-MS RapidTrace Urine

Using the TLC to step gradient is simple and fast requiring only a minute or so to enter the data into the Isolera and create the method. The methods are scalable to larger cartridges increasing purification savings even more.

Posters

Synthesis of branched peptides is very challenging. Here we show the synthesis of a complex multi-branched peptide and how this process can be simplified using Branches™.

Application Notes

We demonstrate the capability of the Biotage® Initiator+ Alstra™ microwave peptide synthesizer to fully automate the on-resin synthesis of cyclic peptides with examples showing disulfide bridge formation and side-chain to side-chain cyclization respectively.

Application Notes

This poster describes the automation of a method for extraction of ochratoxin A from red wine using ISOLUTE Myco SPE columns on the RapidTrace workstation. Presented at Pittcon 2014, Chicago, USA.

Column English Food LC-MS/MS Mycotoxin Ochratoxin A Posters RapidTrace Wine (red)

This guide describes simple practical strategies, hints and tips designed to mitigate or avoid cross-well contamination or ‘cross talk’ in high throughput 96-well based sample preparation techniques.

96-well plate Brochures Clinical English Forensic Pharma

This month’s topic of discussion will be on the drying capability of the DryVap® Concentrator System. The focus will be on how to properly dry your extracts and what to avoid.

Tech Tips

This poster presents a method for detection of approximately 100 drugs and metabolites in urine using mixed-mode polymeric cation exchange solid phase extraction (SPE). Four different glucuronidase enzymes and several incubation times and temperatures were evaluated to determine optimum hydrolysis conditions for seven commonly detected glucuronide metabolites. Samples were subjected to offline hydrolysis and SPE (EVOLUTE® EXPRESS CX, Biotage, Charlotte, NC) and results compared to an SPE plate that incorporates in-well hydrolysis (EVOLUTE HYDRO CX, Biotage). MSACL 2018, Palm Springs, CA

96-well plate Clinical Drugs of Abuse English Forensic Hydrolysed urine LC-MS/MS Pain Management Posters Urine

Extended Warranty SER-XXX-EXW Biotage will provide the following services based upon the terms and conditions set forth in the agreement quotation.

Service Agreement Descriptions

Factory Service Agreement SER-XXX-SAF Biotage will provide the following services based upon the terms and conditions set forth in the agreement quotation.

Service Agreement Descriptions

First Year Maintenance Plan SER-XXX-FYMP Biotage will provide the following services based upon the terms and conditions set forth in the agreement quotation.

Service Agreement Descriptions

The definitive guide to flash chromatography. This document presents in detail the broad selection of ways that materials for purification can be loaded onto a flash cartridge.

Manuals & User Guides

This brochure presents the extensive range of instrumentation for flash purification from Biotage. To complement these products Biotage also offers a complete range of flash consumables, including columns in a variety of sizes packed with irregular and spherical silica, making Biotage your one-stop partner for your flash purification needs. Keywords: Isolera™ Dalton, Isolera™ Spektra, 10 Isolera™ Spektra One and Four, Isolera™ Spektra LS (Large Scale), Isolera™ Prime, Isolera™ ELSD-1080, Biotage® Flash 75/150, Biotage® Flash 400

Brochures