Part No: PPS443.V.1Issued year: 2019File size: 2.98mbFile type: pdf
Analysis of drug panels in urine samples can be challenging, and the trend towards larger panels including multiple drug classes compounds the issues faced during method development.
This white paper examines a number of aspects of sample preparation, and their impact on the success of subsequent LC-MS/MS analysis of broad urine panels.
Section 1 examines the applicability of various sample preparation techniques: supported liquid extraction, reverse phase SPE and mixed-mode SPE, to the various classes of drugs extracted. In addition, hydrolysis approaches: enzyme type and protocol used (time, temperature), are compared.
Mixed-mode reverse phase/cation exchange SPE is widely used for extraction of basic drug classes from urine, but the inclusion of drugs and metabolites that exhibit ‘non-typical’ functionality within urine panels can be problematic. Section 2 examines the impact of various parameters (interference wash strength, elution solvent composition) on analyte retention, elution and extract cleanliness with particular focus on zwitterionic (gabapentin, pregabalin) and non-ionic (carisoprodol, meprobamate) drugs.
Part No: Issued year: 2011File size: 0.07mbFile type: pdf
Through innovative patented technology based on molecularly imprinted polymers (MIPs)
you will experience improved clean up in your processes. With a high probability of success,
unwanted contaminants or high value desirables can be selectively extracted from your
processes, resulting in more efficient production and cleaner products.
Part No: P102Issued year: 2014File size: 0.6mbFile type: pdf
Designed polymers are a class of selective resins with engineered selectivities for particular target molecules or ‘classes’ of molecules. These designed polymers are obtained by careful tuning of their surface chemistry and morphology which allows them to exhibit unique separation capabilities. The tailored and optimized selectivity of designed polymers is utilized to conduct difficult separations that are not able to be accomplished with conventional separation resins or other techniques.
Part No: AN954Issued year: 2010File size: 0.09mbFile type: pdf
This paper demonstrates how the introduction of simple automated technology and a modification in analysis. Can
positively impact analytical results and overall throughput for critical environmental testing.
Part No: AN053-HORIssued year: 2015File size: 1.3mbFile type: pdf
Carbaryl, a commonly used insecticide for the past 20 years, has become a significant environmental concern throughout the world. Also known through its trademarked name Sevin, it is a cholinesterase inhibitor and can be toxic to humans, causing problems in the blood, nervous, and reproductive systems.
Part No: AN089-HORIssued year: 2014File size: 2.48mbFile type: pdf
Deoxynivalenol is a common mycotoxin found in agricultural grain crops and final consumer processed products. Most impacted are wheat, barley, and corn. Deoxynivalenol, also known as Vomitoxin, is produced by Fusarium fungi and has a unique dual-stage growth cycle of producing mold during warm daylight and toxin during cool nights. There is no known procedure or processing that will remove deoxynivalenol that is already present in grain.
Part No: AN001-HORIssued year: 2015File size: 1.35mbFile type: pdf
Hormones in drinking water are a growing concern, since the presence of these compounds can potentially be linked to serious health hazards such as human developmental and reproductive side-effects. Hormones are introduced into our environment in several ways. Natural and synthetic hormones that are given to livestock, pass though the animals, runoff into surface water, and leach into underground water supplies. Humans also produce and excrete natural hormone waste every day.
Part No: AN012-HORIssued year: 2010File size: 0.99mbFile type: pdf
The second Unregulated Contaminant Monitoring Regulation (UCMR2) program was developed to monitor US drinking water sources for currently unregulated compounds. EPA Method 529 is categorized under List 1, Assessment Monitoring in the UCMR2 program, and focuses on three explosives: 1,3-dinitrobenzene; 2,4,6- trinitrotoluene (TNT); and hexahydro-1,3,5-trinitro-1,3,5- triazine (RDX). The resulting data will be used by the EPA to determine whether or not regulatory standards should be established for these compounds.
Part No: AN057-HORIssued year: 2010File size: 0.72mbFile type: pdf
At present, pollution of freshwater algae has become aglobal environmental problem. Of all the different pollution types, microcystin LR is the most toxic and the most acute hazard as far as is known presently