Extrahera GLP Sample Batch Work List (SBWL) 48 Column Rack, vertical format

English Software

Extrahera GLP Sample Batch Work List (SBWL) 48-well plate, horizontal format

English Software

Extrahera GLP Sample Batch Work List (SBWL) 48-well plate, vertical format

English Software

Extrahera GLP Sample Batch Work List (SBWL) 96-well plate, horizontial format

English Software

Extrahera GLP Sample Batch Work List (SBWL) 96-well plate, vertical format

English Software

User report: Initiator. Prof. Nakamura at the Gakushuin University has described the Initiator as an essential tool for his group’s cutting-edge research. We asked Prof. Nakamura for his views on the latest trends in the fields of organic synthesis and drug discovery.

Customer Cases

This poster outlines a new method for the extraction of a mixture of peptides from plasma using resin based SPE. Initial method optimization was performed using EVOLUTE ABN before comparison to the streamlined approach without plate conditioning and equilibration using EVOLUTE EXPRESS ABN. Presented at EBF 2012. EBF, EBF 2012, Peptide, ABN, SPE, Polymer, Polymeric,

ACTH (1-24) Alpha-Endorphin Angiotensin Fragment 1-7 Angiotensin II, Elafin Helicobacter pylori (2-20) LC-MS/MS Myelin Glycoprotein fragment (35-55) rat Peptides Pharma Plasma Posters Vasoactive Intestinal Fragment 1-12

This poster describes the use of EVOLUTE® ABN and EVOLUTE® EXPRESS ABN for the fast and efficient extraction of a diverse mixture of peptides spiked into biological matrices. Pittcon 2014

96-well plate ACTH (1-24) Angiotensin Fragment 1-7 Angiotensin II, Clinical Elafin Endorphin English Glycoprotein myelin Helicobacter pylori (2-20) LC-MS/MS Peptides Pharma Plasma Posters Serum Vasoactive Intestinal Fragment 1-12

The rapid synthesis of the non-steroidal anti-inflammatory agent Fenclofenac (2-(2,4-dichlorophenoxy)phenyl acetic acid) under microwave irradiation is reported. Modified reaction conditions of traditional Ullmann ether coupling resulted in high yields of the diaryl ether. The Willgerodt–Kindler transformation and subsequent hydrolysis of thioamide resulted in 52% overall yield of Fenclofenac.

Application Notes

This application note uses the Biotage® Horizon 4790 automated extraction system with a DVB SPE disk to extract an aqueous sample for PAH compounds analysis. The extract is dried using the Horizon Technology DryDisk®.

1-methylnaphthalene 2-methylnaphthalene 3-methylcholanthrene Acenaphthene Acenaphthylene Acenapthalene Anthracene Application Notes Benzo (a) Anthracene Benzo (a) Pyrene Benzo (b) fluoranthene Benzo (g,h,i) perylene Benzo (k) Fluoranthene Benzo(a)anthracene Benzo(a)pyrene Benzo(b)fluoranthene Benzo(k)Fluoranthene Chrysene English Environmental Fluoranthene GC-MS Napthalene PAHs Perylene-d12 Phenanthrene Polyaromatic Hydrocarbons (PAH) Polyaromatic hydrocarbons Water

This application note describes the fast extraction and quantitation of 10 different antidepressant drugs in urine using ISOLUTE SLE+ 1 mL columns.

Amitriptyline Clinical Clomipramine Column Desipramine Doxepin English Forensic Imipramine Nortryptiline Paroxetine Sertraline Tricyclic Antidepressant Trimipramine Urine

The screening of patient urine samples for basic drugs is typically performed following a lengthy sample preparation methodology that requires a time consuming dry down step. A novel elution protocol coupled to the EVOLUTE EXPRESS advanced plate technology affords a fast sample preparation solution that follows a LOAD-WASH-ELUTE-ANALYZE strategy. Basic drugs are fortified into urine and extracted in 3 easy steps using EVOLUTE EXPRESS CX solid phase extraction in a 96-well plate format.

6-acetyl codeine 6-acetylmorphine (MAM) 96-well plate Alprazolam Application Notes Basic Buprenorphine Clinical Clonazepam Codeine Diazepam Drugs of Abuse EDDP English Fentanyl Flunitrazepam Forensic Hydrocodone Hydromorphone LC-MS/MS Morphine Naltrexone Nitrazepam Normeperidine Oxazepam Oxycodone Oxymorphone Pain Management Temazepam Urine

This application note describes a method of extraction for metanephrine and normetanephrine from pooled plasma using EVOLUTE® EXPRESS WCX 96-well SPE plates. A new solid phase extraction technology has been developed to reduce the time associated with sample preparation methods by eliminating traditional steps in the extraction workflow. Leveraging this technology, a method protocol was developed using a load, wash and elute approach. This method was optimized for pooled plasma.

96-well plate Application Notes Catecholamines Clinical English LC-MS/MS Metanephrine Normetanephrine Plasma

This application note describes a method of extraction for metanephrine and normetanephrine from synthetic urine using EVOLUTE® EXPRESS WCX 96-well SPE plates. A new solid phase extraction technology has been developed to reduce the time associated with sample preparation methods by eliminating steps in the extraction workflow. Leveraging this technology, a method protocol was developed using a load, wash and elute approach. This method was optimized for synthetic urine.

96-well plate Application Notes Catecholamines Clinical English LC-MS/MS Metanephrine Normetanephrine Synthetic urine

This application note describes a method for sample preparation of different matrixes prior to amino acid analysis according to IS ISO 13903:2005 or the similar AOAC Official Method 994.12 using Biotage® Initiator+ to speed up the process.

Application Notes

User Report: Syro I, University of Tokyo. The Suga Laboratory at RCAST, University of Tokyo, uses the Biotage Syro I automated peptide synthesizer for scaling up the chemical synthesis of non-standard peptides.

Customer Cases