Part No: TN/UG-0028.0509Issued year: 2009File size: 0.39mbFile type: pdf
The Isolera leak detection system is designed with safety in
mind. Unlike vapor sensing devices with unreliable solvent
vapor sensitivity, the Isolera leak detector’s sensitive,
solvent-resistant refractive index (RI) monitor rapidly
signals the Isolera flash system to stop pumping if any
liquid, volatile or non-volatile, is detected thus protecting
the chemist, system, and lab from potential hazards.
Part No: TN-0024.0210 (2)Issued year: 2010File size: 0.61mbFile type: pdf
TheBiotage Isolera™LS development-scale flash purification
systemdramatically shortens large-scale purification run-times
with flow rates of 50-500mL/minute. Simply select or create a
method, load your sample, and run – it’s that easy. New
advanced features include: solvent-savingGradientOptimization
(GO), the ability to collect fractions on two separatewavelengths,
use of up to four solvents in a single gradient and add a third
With the Biotage Isolera Spektra, new, intelligent, time-saving features such as gradient optimization, λ-All peak detection, and real-time photodiode array (PDA) scanning enable chemists to purify more compounds in less time and reduce post-process purity analysis.
Part No: PPS314Issued year: 2013File size: 0.46mbFile type: pdf
A new Biotage innovation allows organic chemists to deliver high purity
compounds in the minimum amount of time using minimum amounts of solvent.
Chemists simply enter TLC data and follow the Isolera™ Spektra software’s
method recommendations, based on knowledge gained over 20 years of
experience in automated flash chromatography leadership.
Part No: PN413Issued year: 2003File size: 0.03mbFile type: pdf
Traditional liquid-liquid extraction, carried out in vials, can be difficult to automate. ISOLUTE Array
HM-N plates for supported liquid extraction offer an easy to automate alternative to this popular sample
preparation technique, eliminating the need to physically separate immiscible layers. Each step is a
simple liquid transfer or addition, and no mixing is required.
Part No: Issued year: 2008File size: 0.07mbFile type: pdf
This method selection guide is designed to minimize the choices required to optimize the Supported Liquid Extraction method. The buffer and solvent suggestions provide a range of pHs and solvent polarities for acidic, neutral and basic drugs of varying pKa and logP values. The selections are based on extensive work in Biotage’s R&D Laboratories.
This guide describes how to develop supported liquid extraction methods using ISOLUTE® SLE+ products, along with hints and tips for optimizing performance and extending the range of analytes that can be extracted
Part No: TN417Issued year: 2007File size: 0.1mbFile type: pdf
The introduction of parallel synthesis in pharmaceutical R&D has resulted in the need for purification systems
that allow for increased throughput. With reactions being carried out in a microplate footprint, it is important that the reaction workup can also be performed in this way.When using the 96-well format, there are limitations on both the reaction scale and also the sorbent capacity for the purification step. Using a 24-well system allows for greater sorbent masses to be utilized, increasing the scale of purification.
Part No: TN-0025.0710Issued year: 2010File size: 0.32mbFile type: pdf
ISOLUTE® ENV+ is a hyper-cross linked polystyrene polymer sorbent capable of extracting a wide range of polar and water soluble analytes from a variety of matrices. The optimized surface area, pore structure and absence of fines makes ISOLUTE ENV+ a highly effective and efficient solution to the traditionally difficult extraction of very polar analytes. ISOLUTE ENV+ enables high recoveries at high flow rates making it the SPE column of choice for a variety of environmental and agrochemical applications.
Part No: TN109Issued year: 2004File size: 0.07mbFile type: pdf
This technical note includes a general discussion on non-polar sorbents (page 1), specifics on the use of ISOLUTE ENV+ for the extraction of polar analytes from aqueous samples (page 2), and ordering information (page 5).
Part No: TN142Issued year: 2009File size: 0.26mbFile type: pdf
This Chemistry Data Sheet provides procedures for both the automated and manual fractionation of EPH in soil. The
automated procedure is described on page 2 and the manual procedure is outlined on page 3. Chromatograms
illustrate the ability of ISOLUTE EPH to provide efficient fractionation of hexane or pentane soil extracts into
aliphatic and aromatic fractions (see Appendix).
Part No: TN411Issued year: 2007File size: 0.12mbFile type: pdf
Sample preparation techniques such as protein precipitation, supported liquid extraction or non-polar SPE may not be selective enough to give extracts of sufficient purity for low level analysis. In these cases, the selective mixed-mode approach to the extraction of basic and acidic drugs is a suitable alternative, giving very high purity extracts with minimal levels of co-extracted material.