Part No: SS-INT.R 0611Issued year: 2011File size: 1.28mbFile type: pdf
The 60-position sample bed supports the production of focused libraries, multi-user environments and scale-out. Flexible operation enables the use of both large and small vials in combination at any time and in any order without manual intervention.
Part No: Issued year: File size: 0.18mbFile type: pdf
Solid-phase synthesis combined with fast and
precise heating by microwave irradiation has
become a valuable tool for peptide chemists. It
enables easier solid-phase assembly of difficult
peptide sequences and even small proteins. Here
we present, a study of microwave assisted solidphase
peptide synthesis using different resins on
the Syro WaveTM. Furthermore, we use this
methodology to synthesize difficult peptide
sequences including a multiple display
Part No: Issued year: File size: 0.45mbFile type: pdf
This paper evaluates solvent effect upon flash chromatography purification. The impact of sample mass overloading, volume overloading and sample dissolution solvents upon sample resolution are discussed.
Part No: AN102-HORIssued year: 2016File size: 1.5mbFile type: pdf
n-Hexane-extractable material (HEM), often termed oil & grease, is an operationally-defined general measurement used around the world to help assess water pollution due to a variety of hydrocarbons, including dissolved aromatics, benzene, toluene, xylene and dispersed polynuclear aromatic hydrocarbons (PAHs), aliphatics, naphthenic and fatty acids.1
Part No: TN0021.0707Issued year: 2007File size: 0.36mbFile type: pdf
MP-Borohydride is a macroporous, resinbound borohydride that is a resin bound equivalent of tetraalkylammonium borohydride. The bound borohydride is a versatile reducing agent1,2,3 used for the reduction of carbonyl compounds and imines, and the reductive amination of aldehydes and ketones (Scheme 1). While the free form reagent is generally used in large excess and requires extraction of the reaction mixture for workup, the resin bound form can be used in slight excess and removed easily via filtration of the resin. The resin is compatible with microwave heating, which reduces the reaction time from hours to minutes4.
Part No: TN509Issued year: 2003File size: 0.12mbFile type: pdf
MP-TsO-TEMPO is a macroporous polystyrene-bound equivalent of oxoammonium p-toluenesulfonate. The
resin has primary applications in the oxidation of activated primary and secondary alcohols to their
corresponding aldehydes and ketones under mild reaction conditions.MP-TsO-TEMPO has been found to be
highly selective for oxidation of allylic, benzylic and alicyclic hydroxy compounds.Oxidations with
MP-TsO-TEMPO are very clean and the product is isolated by filtration of the resin followed by solvent removal.
Part No: TN506Issued year: 2004File size: 0.07mbFile type: pdf
MP-TsOH(65) columns have been designed specifically for isolation and purification of amines. The columns may also be used to scavenge basic reagents, substrates and reaction byproducts. A range of configurations is available from 100 mg/3 mL to 2.5 g/25 mL, including tab-less 3 and 6 mL for 48 and 24- well applications respectively. See page 6 for ordering information.
Part No: Issued year: 2005File size: 0.61mbFile type: pdf
• Outline our plans to use catalysis in synthesis and our designs on the subject utilizing small, densely-functionalized building blocks
• Discuss mechanistic issues surrounding regio- and chemoselectivity in oxidative addition with Pd in situations where a number of functional groups can be activated
• Demonstrate the concepts put to practice in natural products synthesis
• Discuss some of our catalysis work in the context of microwave-assisted organic synthesis (MAOS) and its application to library preparation
• Outline directions that we are taking with library preparation utilizing a newly designed micro flow reactor system that is driven by microwave irradiation
• Multi-component reactions (MCR) in micro channels using flow MAOS
Part No: Issued year: 2009File size: 0.43mbFile type: pdf
The MultiSynTech Company develops accessories for peptide and combinatorial chemistry, as well as for automated synthesis. Our synthesis machines are used for parallel synthesis on solid phase as well as for solution chemistry. The multiple, fully automatic synthesis robot SYRO and the semi-automatic synthesis stations SAP, SAM and SAS are used in wide areas of organic chemistry, medicinal chemistry and also academic research for the synthesis of peptides and substance libraries for small molecules.
Part No: Issued year: 2009File size: 0.43mbFile type: pdf
Die Firma MultiSynTech entwickelt Hilfsmittel für die Peptid- und kombinatorische Chemie sowie für automatisierte Synthesen. Unsere Syntheseautomaten werden für die Parallelsynthese an fester Phase, wie auch für die Chemie in Lösung verwendet. Der multiple, vollautomatische Syntheseroboter Syro, die halbautomatischen Synthesestationen SAP, SAM und SAS werden in weiten Bereichen der organischen Chemie, der medizinischen Chemie wie auch in der Hochschulforschung für die Synthese von Peptiden und Substanzbibliotheken kleiner Moleküle eingesetzt. Für Anwendungen, die eine große Anzahl von Peptiden mit nur geringen Substanzmengen erfordern, haben wir die Tip-Synthese- und Spot-Synthese-Module entwickelt, die im Handumdrehen auf dem Syro installiert werden können. In Zusammenarbeit mit führenden Herstellern von Chemikalien haben wir eine Palette von Peptidreagenzien aufgebaut, die sowohl qualitativ als auch preislich für unsere Kunden Vorteile bietet.
Part No: P166Issued year: 2017File size: 0.7mbFile type: pdf
Utilization of synthetic chemistry routes developed in late lead
optimization is becoming more widespread as the desire to
efficiently confirm pre-clinical compounds has increased. In some
cases, chemical processes use reagents which are specific and
cannot be substituted on scale up. Such reagents include transition
Part No: P123Issued year: 2015File size: 1.39mbFile type: pdf
New, higher default flow rates enabled by Isolera ACI systems decreases purification times compared to other systems’ and cartridges’ default flow rate settings without sacrificing separation efficiency. Incorporation of gradient optimization by converting a linear gradient to a step gradient further reduces purification time and solvent use while maintaining separation integrity for a target molecule.