La cromatografía flash en fase normal y fase reversa facilita el aislamiento de compuestos polares presentes en extractos de productos naturales. La combinación de avanzadas funciones de detección tales como barrido espectral, y evaporativo de luz dispersa (ELSD) incrementa la efectividad de la cromatografía flash en procesos de purificación de productos naturales.

Application Notes Spanish

Alstra™ Remote software. Download UI392 for instructions on installation and activation.

Software

Installatino instructions for Alstra™ Remote software.

Manuals & User Guides

This poster aims to demonstrate workflow advantages for fingernail analysis; multi-sample homogenization, extraction and analysis for a range of drugs of abuse. ASMS 2019

Drugs of Abuse English Forensic LC-MS/MS Nail (human) Posters

Solid matrix analysis by LC/MS or GC/MS is generally more involved due to the necessity of multiple manual steps to convert the sample into an extractable form. This poster aims to demonstrate workflow advantages for fingernail analysis; multi-sample homogenization, extraction and analysis for a range of drugs of abuse. TIAFT 2019 SOFT 2019

96-well plate Amphetamines Anaesthetic Benzodiazepines Clinical Cocaines Column Drugs of Abuse English Forensic LC-MS/MS Lysera Nail (human) Opiates Posters z-drugs

Improvements in solid phase peptide synthesis strategies and development of resin linkages susceptible to low acid cleavage conditions has enabled synthesis of long peptides while keeping the protecting groups intact. This strategy is now used for the preparation of chemically synthesized proteins, wherein shorter peptide fragments are ligated together. They are also found in the synthesis of peptide macrocycles that utilize head-to-tail cyclization strategies. Although linear synthesis of protected peptides is generally straightforward, purification of these compounds using traditional reversed phase methods is quite challenging. Herein we describe the use of normal phase chromatography for purification of fully protected peptides.

Posters

Routine testing for drugs of abuse (DOA) in urine is commonly performed by many clinical, forensic, and pain management laboratories. The method of testing varies but can often provide unwanted load stress for day-to-day operation in labs. Most seek simplified yet reliable and robust modes of sample preparation and analysis. ASMS, 2020.

96-well plate Amitriptyline Clinical Codeine Drugs of Abuse Hydromorphone Lorazepam Morphine Naloxone Norbuprenorphine Oxazepam Oxymorphone Posters THC-COOH Urine

This poster describes an automated procedure for isolation and clean up of 15 F2t-isoprostane (8-iso Prostaglandin 2a)(a lipid marker of oxidative stress) from BSA.

15 F2t-isoprostane 8-iso Prostaglandin2a BSA Biological fluids Biomarker Clinical Column English GC-MS Lipids Posters RapidTrace

Effective removal of residual water from organic solvents is critical to achieve optimal recoveries for water soluble compounds. Sodium sulfate has been the standard technique for removing residual water from solvent extracts for many years; however, it has several major drawbacks. Water soluble analytes in the residual water phase can become adsorbed in the sodium sulfate, leading to lower recoveries.

Application Notes Disk English Environmental GC-MS Organic Compounds Water

This application note describes the extraction of 96 licit and illicit drugs of abuse from urine prior to UPLC-MS/MS analysis using EVOLUTE® HYDRO CX 96-well plates. EVOLUTE® HYDRO CX plates offer an efficient way to perform hydrolysis in the well of the extraction plate. This method provides high analyte recovery, reduced extraction time due to the elimination of a sample transfer step as well as the elimination of the column conditioning and equilibration steps, and a reduced risk for sample carryover or cross-contamination due to the elimination of the sample transfer step.

6-acetyl codeine 6-acetylmorphine (MAM) 7-Aminoclonazepam 7-Aminoflunitrazepam 96-well plate Alprazolam Amitriptyline Amphetamine Amphetamines Analgesics Application Notes Aripiprazole Atomoxetine Barbiturates Benzodiazepines Benzoylecgonine Buprenorphine Bupropion Buspirone Butalbital Carbamate hypnotic Carbamate muscle relaxant Carbamates Carbazepine Carisoprodol Chlordiazepoxide Chlorpheniramine Chlorpromazine Clinical Clomipramine Clonazepam Clonidine Clozapine Cocaethylene Cocaine Cocaines Codeine Cyclobenzaprine Desalkylflurazepam Designer stimulants Dextromethorphan Diazepam Dihydrocodeine (DHC) Drugs of Abuse Duloxetine EDDP English Ethyl Sulfate (EtS) Extrahera Fentanyl Fluoxetine Forensic Gabapentin Haloperidol Hydrocodone Hydrolysed urine Hydromorphone Hydroxyalprazolam Hydroxybupropion Hydroxymidazolam Hydroxytriazolam Imipramine Ketamine LC-MS/MS Lamotrigine Levetiracetam Lidocaine Lorazepam MDA MDEA MDMA Meperidine Meprobamate Methadone Methamphetamine Methaqualone Methcathinone Midazolam Morphine N-des-tapentadol N-desmethylclomipramine N-desmethyltapentadol Naloxone Norbuprenorphine Nordiazepam Norfentanyl Norhydrocodone Norketamine Normeperidine Noroxymorphone Norpropoxyphene Nortryptiline Opiates Opioid Opioid agonist Oxazepam Oxcarbazepine Oxycodone Oxymorphone Pain Management Pentobarbital Pharmaceuticals Phencyclidine (PCP) Phenobarbital Pregabalin Quetiapine Ritalinic acid Secobarbital Stimulants THC-COOH Tapentadol Temazepam Topiramate Tramadol Triazolam Trimipramine Urine Venlafaxine Zolpidem Zolpidem-phenyl-4-COOH mCPP z-drugs

This is the importable .exp method for the application note AN842

25-OH Vitamin D2 25-OH Vitamin D3 25-hydroxy-vitamin D Extrahera

This is the importable .exp method for the application note AN847

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN847

Extrahera MNZOH Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN849

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN850

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN851

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN857

1, 25 Dihydroxyvitamin D 1a, 25-dihydroxy-vitamin D 1α, 25-dihydroxy-vitamin D Extrahera

This is the importable .exp method for the application note AN861

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

Aliphatic hydrocarbons Aromatic hydrocarbons PAHs Polyaromatic Hydrocarbons (PAH) Soil