This is the importable .exp method for the application note AN850

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN851

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN857

1, 25 Dihydroxyvitamin D 1a, 25-dihydroxy-vitamin D 1α, 25-dihydroxy-vitamin D Extrahera

This is the importable .exp method for the application note AN861

Extrahera MMA (Methylmalonic acid) Methylmalonic acid (MMA)

This is the importable .exp method for the application note AN876

PEth Whole blood

Aliphatic hydrocarbons Aromatic hydrocarbons PAHs Polyaromatic Hydrocarbons (PAH) Soil

This application note describes the use of ISOLUTE® ENV+ on-line cartridges in a fully automated on-line SPE-LC-MS/MS method for extraction and quantification of 16 acid herbicides in drinking and surface water.

2,4,5-T 2,4-D 2,4-DB Acid herbicides Application Notes Asulam Benazolin Bentazone Bromoxynil Dicamba Dichlorprop Drinking water English Environmental Ioxynil MCPA MCPB Mecoprop On-line SPE On-line SPE-LC-MS/MS Pentachlorophenol Quinmerac Surface water Triclopyr Water

Catecholamines and Metanephrines were analyzed using a LCMS-8060 triple quadrupole mass spectrometer. Calibrators were prepared in synthetic urine and extracted using solid phase extraction. Extractions were performed using weak cation exchange on the EVOLUTE® EXPRESS WCX 10 mg 96-well plate from Biotage.

Most drugs, both licit and illicit, are excreted in urine as glucuronide conjugates. Hydrolysis using beta-glucuronidase converts the glucuronidated metabolites back to their “free” or non-conjugated form, increasing sensitivity for LC-MS/MS analysis. Hydrolysis using red abalone, abalone, and recombinant beta-glucuronidase enzymes was evaluated using an in-well hydrolysis plate to determine which provided the most efficient hydrolysis of glucuronide metabolites without affecting overall recovery of nonconjugated compounds. A glucuronide control containing 8 glucuronide compounds was used to determine the extent of hydrolysis that occurred. A non-conjugated control containing 96 licit and illicit drugs of abuse was evaluated to determine if signal suppression occurred as a result of enzyme hydrolysis. ASMS 2017

96-well plate Clinical Codeine Drugs of Abuse English Forensic Hydrolysed urine Hydromorphone LC-MS/MS Lorazepam Morphine Norbuprenorphine Oxazepam Oxymorphone Pain Management Posters Urine

Pesticides, including insecticides, herbicides and fungicides are used extensively to increase agricultural yields. The total world usage of pesticides in 2007 was approximately 5.2 billion pounds with the US consuming approximately 22% of the total.1 The wide use of pesticides yields concern that drinking water sources will become contaminated, exposing the population to hazardous substances that may cause cancer.

Application Notes Disk Drinking water EPA 508.1 Analytes English Environmental GC-MS Pesticides

US EPA Method 1664 for Hexane Extractable Material (HEM) or Oil and Grease has allowed use of solid phase extraction (SPE) instead of liquid-liquid extraction (LLE) with hexane since 2007 and this has been widely adopted in the US. SPE is an equivalent extraction technique to LLE and produces the same n-hexane extract. The extract, similar to LLE, may contain residual water that must be treated properly and removed from the n-hexane extract.

Environmental Posters

This application note demonstrates that the Biotage(R) Horizon 4790 using Atlantic C18 disks can effectively extract hormone compounds from 1-L water samples in approx 40 mins.

11-ketotestosterone 17-alpha-estradiol 17-alpha-ethynylestradiol 17-beta-estradiol 4790 Androgens Androsterone Application Notes Diethylstilbestrol Dihydrotestosterone (DHT) Disk Endocrine disrupter English Environmental Epitestosterone Estradiol Estriol Estrogens Estrone GC-MS Hormones Mestranol Norethindrone Progesterone Steroid Hormones Steroid metabolite Surface water Testosterone Water

Analysis of the perfluorinated alkyl acids listed in EPA Method 537 along with fluorotelomeric alcohols and perfluorinated sulfonates were extracted using SPE (using ISOLUTE 101 500 mg/ 6 mL SDVB SPE columns) and analyzed on the LCMS 8045. Minimum Detection Limits(MDL) ranged from 0.69 to 3.25 ppt. Extraction recoveries were greater than 80% for all compounds, with surrogate recoveries within 10% of the true value.

Application Notes Column Drinking water English Environmental LC-MS/MS Polyfluorinated acids

This application note demonstrates the use of automated solid phase extraction for a variety of pharmaceutical compounds in drinking water, wastewater and surface water. The criteria specified in US EPA Method 1694 was met, even at very low concentrations. For lower concentrations a larger sample of water may be processed.

4790 Acetaminophen Albuterol Albuterol Application Notes Atenolol Caffeine Carbamazepine Cotinine DEET Dehydronifedipine Diclofenac Diltiazem Diphenhydramine hydrochloride Disk Drinking water English Environmental Gemfibrozil Ground water Ibuprofen LC-MS TOF Lamotrigine Metoprolol Naproxen Pharmaceuticals Sulfadimethoxine Sulfamethoxazole Triclocarban Trimethoprim Waste water

This application note describes the use of EVOLUTE® EXPRESS ABN on-line cartridges in a fully automated on-line SPE-LC-MS/MS method for extraction and quantification of 13 commonly prescribed pharmaceuticals (with a range of characteristics) in water.

Application Notes Atenolol Atorvastatin Azithomycin Carbamazepine Ciprofloxacin Clarithromycin Diclofenac English Environmental Erythromycin Fluoxetine On-line SPE On-line SPE-LC-MS/MS Pharmaceuticals Prednisolone Ranitidine Sertraline Tolytriazole Water

The method described in this application note achieves high recoveries of THC and an extended suite of common metabolites in oral fluid from Quantisal (Immunalysis) oral fluid collection devices. This application note describes effective and efficient ISOLUTE SLE+ protocols optimized for sample loading volumes of either 300 μL or 800 μL. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 64% with RSDs of <10% for all analytes.

11-hydroxy- Δ9-tetrahydrocannabinol (THC-OH) 11-nor- Δ9-carboxy tetrahydrocannabinol (THC-COOH) 11-nor-9-carboxy- Δ9-tetrahydrocannabivarin (THC-V-COOH) 11-nor-9-carboxy- Δ9tetrahydrocannabinol glucuronide (THC-COOH-g 11-nor-9-carboxy-Δ9-THC glucuronide Application Notes Cannabidiol Cannabigerol Column Drugs of Abuse English Forensic LC-MS/MS Oral fluid Saliva THC THC metabolites THC-COOH Δ9-tetrahydrocannabinol (THC) Δ9-tetrahydrocannabivarin (THCV)

Urine samples are neutralized using 0.5 M ammonium acetate and loaded onto weak cation exchange (WCX) Evolute Express plates (Biotage), preconditioned with methanol and water. Samples are washed with 20 mM ammonium acetate and water before elution in 0.5 % formic acid. Department of Clinical Chemistry and Immunology, Heart of England NHS Foundation Trust, Birmingham, UK

Posters

Pesticides have gone far in increasing food supply, important in a world expecting to have 9.8 billion people by 2050. However, the mechanisms that make pesticides effective in eliminating pests can also cause harm to humans and animals. News stories continue to point to contamination through spills and exposure through the respiratory system.

5000 Application Notes Disk EPA 608.3 Analytes English Environmental GC-MS US EPA Method 608.3 Waste water

In this catalog product information is displayed with easy-to-follow application details and supporting documentation. Ordering information is found following each product listing.

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Annual Maintenance Contract - India

Product Notes