This application note demonstrates the use of automated solid phase extraction for a variety of pharmaceutical compounds in drinking water, wastewater and surface water. The criteria specified in US EPA Method 1694 was met, even at very low concentrations. For lower concentrations a larger sample of water may be processed.

4790 Acetaminophen Albuterol Albuterol Application Notes Atenolol Caffeine Carbamazepine Cotinine DEET Dehydronifedipine Diclofenac Diltiazem Diphenhydramine hydrochloride Disk Drinking water English Environmental Gemfibrozil Ground water Ibuprofen LC-MS TOF Lamotrigine Metoprolol Naproxen Pharmaceuticals Sulfadimethoxine Sulfamethoxazole Triclocarban Trimethoprim Waste water

Atlantic® ReadyDisks are solid phase extraction (SPE) disks, pre-assembled into disposable holders and are used for extracting organic and semivolatile organic compounds from aqueous matrices. The ReadyDisks are designed for single-use extractions with maximum speed and convenience in mind and eliminate the need to clean holders between extractions.

Disk Drinking water EPA 525.2 Analytes EPA 525.3 Analytes English Ground water Product Notes SVOC Semi-Volatile Organics Surface water US EPA Method 525.2 US EPA Method 525.3

Polycyclic aromatic hydrocarbons (PAHs) can be found in a number of water types, such as drinking water, surface water, ground water and wastewater. There are serval types of extraction techniques that can be implemented to remove them from water for measurement including liquid-liquid extraction (LLE), continuous liquid-liquid extraction (CLLE) and solid phase extraction (SPE). With LLE and CLLE there is little selectivity within the methods for difficult matrices or other compound interferences.

5000 Application Notes Disk Drinking water English Environmental GC-MS Ground water PAHs Polyaromatic Hydrocarbons (PAH) Waste water

The purpose of this application note is to demonstrate the capabilities of the Biotage® Horizon 4790 Automated Extractor System when used for the analysis of nitramine, nitroaromatic, and nitrate ester compounds in surface and ground water.

1,2-Dinitrobenzene 1,3,5-trinitrobenzene 1,3-dinitrobenzene 2,4,6-trinitrotoluene (TNT) 2,4-dinitrotoluene 2,6-dinitrotoluene 2-amino-4,6-dinitrotoluene 2-nitrotoluene 3-nitrotoluene 4-amino-2,4-dinitrotoluene 4-nitrotoluene 4790 Application Notes Disk EPA 8330B Analytes English Environmental Explosives Ground water HMX HPLC RDX Surface water US EPA Method 8330B nitrobenzene

The purpose of this application note is to demonstrate the capabilities of the automated Horizon Technology solution when used for the analysis of EPA method 8061A phthalate ester compounds in surface and ground water. Method 8061A states gas chromatography/mass spectrometry (GC/MS) can be used as an alternative for compound confirmation for phthalate esters.

4790 Application Notes Disk EPA 8061A Analytes English Environmental GC-MS Ground water Phthalates Phthalic acid esters Surface water

Method 508.1 is used to determine twenty-nine chlorinated pesticides, three herbicides, and four organohalides in ground water, drinking water, and water in any treatment stage. The analytes are extracted from the water using a 47 mm C18 disk. The disk is extracted on the Horizon Technology SPE-DEX® 4790 Automated Extraction System using Ethyl Acetate and Methylene Chloride (DCM). The extract is then dried and concentrated using the Horizon Technology DryVap® with DryDisk® technology. Final analysis is by GC/ECD.

Application Notes Chorinated Pesticides Drinking water English Environmental GC-MS Ground water Herbicides Organohalides Pesticides US EPA Method 508.1 Water

This application note describes the use of Atlantic® ReadyDisk C18 SPE disks for the automated extraction of EPA 525.2 analytes, using the Biotage® Horizon 5000 extraction system.

5000 Application Notes Disk Drinking water EPA 525.2 Analytes English Environmental GC-MS Ground water Surface water US EPA Method 525.2

This application note describes the use of Atlantic® ReadyDisk DVB SPE disks for the automated extraction of EPA 525.3 analytes from drinking water, using the Biotage® Horizon 5000 extraction system.

Application Notes Disk Drinking water EPA 525.3 Analytes English Environmental Ground water SVOC Semi-Volatile Organics Surface water US EPA Method 525.3

This application note describes the use of Atlantic® ReadyDisk HC-C18 SPE disks for the automated extraction of EPA 525.2 analytes from drinking water, using the Biotage® Horizon 5000 extraction system.

Application Notes Disk Drinking water EPA 525.2 Analytes English Environmental Ground water SVOC Semi-Volatile Organics Surface water US EPA Method 525.2

Semivolatile organic compounds (SVOC) have a variety of chemical properties that have been found to cause harmful effects to both humans and the environment. Accurate measurements are challenging to obtain because SVOCs readily adsorb onto surfaces, and are found in common household items such as cleaning agents, personal care products, electrical components, pesticides, water and food.

5000 Application Notes Disk EPA 8270 Analytes English Environmental GC-MS Ground water SVOC Semi-Volatile Organics US EPA Method 8270D

EPA Method 8141B describes the performance based procedure to determine low ppb levels of organophosphorous pesticides in ground water. The OP pesticides are extracted using solid phase extraction (SPE) based on the procedure outlined in Method 3535A for OP pesticides by Method 8141. The analysis is performed with capillary GC using a FPD (flame photometric detector). This initial demonstration of capability was conducted using the Biotage® Horizon 4790 Automated Extractor System.

4790 Application Notes Azinphos methyl Chlorpyrifos Demeton (O&S) Diazinon Disk Disulfoton EPN English Environmental Ethion Ethyl parathion GC-FPD Ground water Malathion Methyl parathion Organophosphate Pesticide Organophosphates US EPA Method 8141

The chemical 1,4-dioxane is primarily used as an industrial solvent or solvent stabilizer. Its carcinogenic classification by US EPA in Group B2 and by the state of California in Proposition 65 (safe harbor limit of 30 μg/day) along with its more recent detection in multiple groundwater supplies across the US have led to its placement on the UCMR 3 list to evaluate its occurrence in drinking water supplies. This has increased demand for testing.

1,4-dioxane Application Notes English Environmental Ground water SmartPrep

The purpose of this application note is to demonstrate the use of a fully automated solid phase extraction (SPE) and concentration system that provides fast sample preparation while improving the quality and consistency of results for the Total Petroleum Hydrocarbon (TPH) compounds from C10 to C40 as dictated by EPA Method 8015.

4790 Application Notes Disk EPA 8015 Analytes EPA 8015 analytes English Environmental GC-FID Ground water Hexane Extractable Material Surface water Total Petroleum Hydrocarbons (TPH, SGT-HEM) US EPA Method 8015

User instructions for Atlantic® ReadyDisk DVB

Disk Drinking water EPA 525.3 Analytes English Environmental Ground water Manuals & User Guides SVOC Semi-Volatile Organics Surface water US EPA Method 525.3

User instructions for Atlantic® ReadyDisk HC-C18

Disk Drinking water EPA 525.2 Analytes English Environmental Ground water Manuals & User Guides SVOC Semi-Volatile Organics Surface water US EPA Method 525.2