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A Seminal Supported Resin for Reductive Amination

18 April 2016

Biotage® MP-Triacetoxyborohydride is a macroporous polystyrene-supported equivalent of tetraalkylammonium triacetoxyborohydride. The resin has primary applications in the reductive amination of aldehydes and ketones under neutral or mildly acidic reaction conditions.


Sodium triacetoxyborohydride has emerged as one of the reagents used most frequently for carrying out reductive amination of carbonyl compounds, a reaction that is also known as reductive alkylation of amines. A disadvantage of sodium triacetoxyborohydride is its poor solubility, and that product isolation requires an aqueous quench followed by liquid-liquid extraction and column chromatography.

Biotage® MP-Triacetoxyborohydride was developed to perform in a manner similar to that of sodium triacetoxyborohydride, while simplifying reagent handling and product purification. Moreover, for many of these reactions, a scavenger resin may be added for one-pot purification of the product.

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Related Documents

Biotage® MP-Triacetoxyborohydride Polymer-Supported Reducing Agent

Part No: PPS391.V.1 Published: 2016 1.79 MB Format: pdf