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Extraction of Desmopressin from Serum Using EVOLUTE® EXPRESS WCX Prior to LC-MS/MS Analysis

24 October 2017

This application note from Biotage describes a solid phase extraction (SPE) protocol for the extraction of the peptide desmopressin from human serum prior to LC-MS/MS analysis.


Desmopressin is an antidiuretic hormone and a synthetic vasopressin analogue. Desmopressin is clinically used to treat bedwetting (nocturnal enuresis), diabetes insipidus and may also be used for clotting disorders.

The method described in this application achieves high reproducible extraction recoveries of desmopressin peptide from serum while minimizing co-extractable material in the form of proteins, lipids and phospholipids. Extraction from serum was performed using EVOLUTE® EXPRESS WCX 96-well plates.

EVOLUTE® EXPRESS SPE products provide robust, efficient, high throughput automatable extraction solutions.

Download the Application Note Below



  • Desmopressin

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