The research groups of Prof. Blixt and Prof. Jensen at the University of Copenhagen have described a high-throughput O-glycopeptide discovery platform for seromic profiling, using the Syro II parallel peptide synthesizer for high-throughput glycopeptide synthesis where over 1700 O-glycopeptides were synthesized for the construction of novel peptide microarrays.This approach provided multiwell low scale synthesis of peptides and GalNAc-glycopeptides combined with direct printing without prior purification for a facile and economical approach to display hundreds of glycopeptides. Biomarker microarrays are becoming valuable tools for serological screening of disease-associated autoantibodies.
The research for this application note was carried out in the groups of Prof. Ola Blixt and Prof. Knud J. Jensen at the University of Copenhagen.
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