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Simplified Synthesis of Complex Peptide Modifications

29 December 2014

Branched peptides are of great interest due to their thera­peutic potential and many interesting peptides have a branched structure such as multiple antigenic peptides (MAP) and peptidoglycans.


This application note describes the synthesis of a branched peptidoglycan mimic and the synthesis of a tetra-branched antimicrobial peptide analogue (MAP) on a lysine scaffold using Biotage® Initiator+ Alstra™ microwave peptide synthesizer. These peptide modifications are challenging to synthesize and automate, however, the procedure was operationally simplified using Branches™.

The research for this application note was carried out in the group of Prof. Knud J. Jensen at the University of Copenhagen.


Branched peptidoglycan mimic (left) and Tetra-branched antimicrobial peptide analogue (MAP).

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