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SLE Method for Detecting NBOMes in Oral Fluid

06 March 2015

A successful method for detecting NBOMes in oral fluid is presented in this poster. Of the three compared techniques (SLE, SPE and LLE), SLE produced comparable or better recovery using less sample volume and less solvent in shorter time. 


NBOMes are a series of drugs of abuse usually taken under the tongue on blotter paper. They are sometimes mistaken for Ecstasy or LSD. Insufficient data exists about NBOMes - it is thought that they interact with the serotonin neurotransmitter in the brain. General effects include hallucinations, tachycardia and seizures. Death can result at low levels. 

Currently, there is no literature on the detection of NBOMes in oral fluid. However, detecting these and other novel psychoactive substances in oral fluid is of value. Since NBOMes are primarily administered sublingually, it is probable that the drugs may contaminate the oral mucosa as well as accumulate in oral fluid due to ion trapping after passively diffusing from the blood into oral fluid.

More on NBOMes

NBOMes ((2,5-dimethoxyphenyl)-N-[(2- methoxyphenyl)methyl]ethanamine) are a class of novel psychoactive substances (NPS) that are derived from a specific group of substituted phenethylamines – the 2C series. The 2C series contains methoxy groups on the 2 and 5 positions of a benzene ring of the phenethylamine backbone structure. NBOMes have an additional 2-methoxybenzyl on the nitrogen backbone of the 2C series, which is believe to result in increased potency.

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