The formation of diarylethers by reacting an arylhalide and phenol is usually a reaction demanding long reaction times, high temperatures and strong bases, in order to obtain acceptable yield. The substitution patent of the electrophile and the nucleophile affects the reaction times mostly. A sterically hindered electrophile and a strongly deactivated nucleophile as outlined in the (Scheme 1) below, gives a very low yield (13 %) at conventional reflux for 2 weeks.1,2 Remainder was recovered starting material. We have previously reported the dramatically shortened reaction time to 1 hour along with improved yield running the reaction outlined in the Scheme by heating by microwaves.
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Biotage has developed a range of tools to improve the peptide synthesis workflow, from synthesis of crude peptides through to the final purified product. These solutions make your workflow more efficient and improve the quality of peptides you synthesize. Our workflow solutions are used in pharma, biotech, CRO and academic laboratories throughout the world.
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The application of microwave irradiation in solid phase peptide synthesis (SPPS), is an important tool for the synthesis of difficult and long peptide sequences that are often obtained in poor quality by comparable conventional methods at room temperature. Here we present the results obtained for the synthesis of a number of difficult peptide sequences using different levels of automation for microwave assisted SPPS: manual, semi-automated and fully automated systems. Syro wave, initiator, sp wave
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The Biotage® Initiator PeptideWorkstation is an accessory to perform manual microwave peptide synthesis and cleavage utilizing the Biotage Initiator microwave synthesizer.
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