C-terminal peptide aldehydes are key components in oxime and hydrazine ligations and their synthesis is therefore very desirable. A well established method for the synthesis of C-terminal modified peptides including peptide aldehydes, is the backbone amide linker (BAL) strategy (Scheme 1).1 In this strategy, the first amino acid is anchored by reductive amination followed by acylation of the newly formed secondary amine. Thus, the growing peptide chain is anchored not through the C-terminal carboxyl but through a backbone amide nitrogen giving access to, in principle, any C-terminal modification.
Tags: Application Notes

Biotage has developed a range of tools to improve the peptide synthesis workflow, from synthesis of crude peptides through to the final purified product. These solutions make your workflow more efficient and improve the quality of peptides you synthesize. Our workflow solutions are used in pharma, biotech, CRO and academic laboratories throughout the world.
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On Aug 30, 2017 a scientific literature search for the keywords Biotage AND peptide was performed by Biotage personnel. The search identified 5380 peer-reviewed publications from the global community, excluding patents and simple citations. Below are approximately 100 titles illustrating the breadth and depth of research in which Biotage tools are utilized.
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Translated versions of the Safety chapter available in the Biotage® Initiator+ Installation and Safety document (P/N 355976). Languages: Danish, Dutch, Finnish, French, German, Italian, Japanese, Spanish, and Swedish.
Tags: Danish, Dutch, Finnish, French, German, Italian, Japanese, Manuals & User Guides, Spanish, Swedish

Biotage® Initiator Installation and Safety
Tags: English, Manuals & User Guides

Tags: English, Manuals & User Guides

This poster presents the synthesis of peptidoglycan fragments where the coupling of peptides and carbohydrates was achieved using microwave heating. The fully automated total synthesis of a complex branched peptide is also presented. The fragments were synthesized using Biotage® Initiator+ SP Wave, Biotage® Syro Wave™ and Biotage® Initiator+ Alstra™ respectively. Presented at EPS, Sofia, 2014.
Tags: Posters

We have successfully developed a rapid and efficient microwave-assisted protocol for the preparation of Neu5Ac congeners that are important intermediates for clinically-relevant derivatives of Neu5Ac. The syntheses were performed using readily available reagents, improved on established techniques, and used more benign reagent for peracetylation. Moreover, the protocol that we developed is 1 to 2 orders of magnitude faster than conventional methods. Initiator+ SPWave synthesis system Dhananjaya Sahoo, I. Abrrey Monreal, and Jonel P. Saludes
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The application of microwave irradiation in solid phase peptide synthesis (SPPS), is an important tool for the synthesis of difficult and long peptide sequences that are often obtained in poor quality by comparable conventional methods at room temperature. Here we present the results obtained for the synthesis of a number of difficult peptide sequences using different levels of automation for microwave assisted SPPS: manual, semi-automated and fully automated systems. Syro wave, initiator, sp wave
Tags: Posters

Introduction • Solid-phase peptide synthesis (SPPS) is still often faced with challenges in the assembly of long and ‘difficult’ sequences, e.g. due to aggregation and steric hindrance giving rise to incomplete reactions. These problems have only partly been solved by new coupling reagents and solid supports. • Precise microwave heating has emerged as one new parameter for SPPS, in addition to coupling reagents, resins, solvents etc.
Tags: Posters

Introduction • Solid-phase peptide synthesis (SPPS) is still often faced with challenges in the assembly of long and ‘difficult’ sequences, e.g. due to aggregation and steric hindrance giving rise to incomplete reactions. These problems have only partly been solved by new coupling reagents and solid supports. • Precise microwave heating has emerged as one new parameter for SPPS, in addition to coupling reagents, resins, solvents etc.
Tags: Posters

Introduction Solid-phase synthesis combined with fast and precise heating by microwave irradiation has become a valuable tool for peptide chemists. It enables easier solid-phase assembly of difficult peptide sequences and even small proteins. Here we present, a study of microwave assisted solidphase peptide synthesis using different resins on the Syro WaveTM. Furthermore, we use this methodology to synthesize difficult peptide sequences including a multiple display antimicrobial peptide.
Tags: Posters

In peptide synthesis mode, this is the perfect tool for chemists synthesizing peptides and peptidomimetics, including difficult modifications and labeling of sequences, by using single or multi-step procedures. The intuitive Initiator 4.0 software controls the instrument functions and by using the pre-defined methods, synthesis can be started immediately.
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