In this application note, we compare the amounts of a threecomponent mixture that can be separated on columns of the same size, 25 g, but with different Silica material: SNAP KP-Sil (average 50 μm irregular particles), Sfär Silica (60 μm spherical particles) and Sfär Silica HC (20 μm spherical particles) using a Biotage® Selekt instrument.
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When purifying molecules, maximizing your efficiency is critical to your daily work. For us at Biotage, helping you to make the most of your time is of paramount importance. That is why we have designed a lean and compact automated flash system with two column channels, so you can prepare channel two while channel one is running.
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Purification is a fundamental step in drug discovery. As pioneers of automated flash purification, Biotage is your ideal partner. When it comes to purification, here are five reasons to Selekt Biotage.
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User Case: Professor Roger Strömberg, Karolinska Institutet. One of Professor Strömberg’s projects at Karolinska Institutet involves the synthesis of artificial nucleases and PNAzymes. In 2013, his research group acquired a Biotage® Initiator+ Alstra™ peptide synthesizer for making PNAs and peptides.
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Translations of the Safety section in the Biotage® Selekt Installation and Safety document (P/N 416182).
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Tags: English, Manuals & User Guides

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Flash purification involves a simple liquid chromatography technique » Method development uses TLC as a way of deciding the parameters for the separation » Isocratic separations are easiest to develop, but gradient separations are more powerful » Software in the Isolera helps with conversion of an isocratic separation to a gradient » It is possible with the Spektra software to run step gradients » Loading options are dependent on the column type » SNAP offers the most flexibility » Care must be taken to choose the best loading option to get good purifications
Tags: Manuals & User Guides

Synthetic chemistry is hard enough; purifying the reaction product can be even more challenging. If your reaction mixture shows you made your target but also many byproducts, what do you do? You can resynthesize using different reaction conditions, use advanced work-up procedures, or you can purify using high-performance flash chromatography.
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Peptide purification via flash chromatography has recently been demonstrated as a viable alternative to the more standard HPLC methods currently utilized. Flash chromatography offers peptide chemists the advantage of significantly greater loading capacity reducing the overall purification time but with a compromise of decreased peak resolution. Herein we present several strategies that, when implemented, allow for very high purity peptide samples purified by flash chromatography.
Tags: White Papers

Die Flash-Chromatographie ist die bevorzugte Reinigungsmethode für organische Stoffe, Arzneimittel und Naturstoffe. In jüngster Zeit hat sie auch die Peptidchemie erobert, verfügt sie doch über die Fähigkeit, eine Vielzahl unterschiedlicher Verbindungen effizienter zu trennen, als dies mit anderen Vorreinigungsverfahren wie z. B. dem Ausfällen (Protein-Crash) oder der Flüssig-Flüssig-Extraktion möglich ist. Zur Herstellung reiner Verbindungen können Chemiker je nach dem gewünschten Reinheitsgrad auf eine Vielzahl unterschiedlicher Variablen zurückgreifen. In diesem Whitepaper möchten wir die Faktoren erläutern, die für eine erfolgreiche Aufreinigung mithilfe der Flash-Chromatographie kontrolliert werden müssen.
Tags: White Papers