
The term “Green Chemistry” has become a major part of the
science community’s lexicon. In this application note we will
look at two areas for flash chromatography:
1. Replacing chlorinated solvents with those considered more
environmentally friendly.
2. Reducing solvent use and waste generation with more
thoughtfully applied chromatography principles.
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Application Notes
Normal-phase flash chromatography1 has been widely adopted as the method of choice for separation of product mixtures and reaction by-products. One of the most significant developments in this
area concerns the practical separation of polar molecules. Reversed-phase purification is a modification of normalphase
chromatography that provides an efficient mechanism for the separation of polar compounds.
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Application Notes,
Brochures,
English,
Manuals & User Guides
Pyrazines are a class of organic molecules often used to provide flavor to foods. They are typically synthesized but some are found in fruits and vegetables, e.g. grapes, bell peppers, peas, asparagus, beetroot, tobacco, and roasted foods. Pyrazine’s heterocyclic chemistry can yield some challenges to their purification due to the various separation kinetics between the compound and silica. Biotage SNAP Ultra.
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Application Notes,
English
Biotage has developed tools for every
step of the organic process, with the entire workflow in mind.
This dedicated suite of products vastly expands the
range of options in order to truly accelerate discoveries
of new molecules for future innovations.
Tags:
Brochures
Flash purification is a separation technique developed in 1978 by Professor W.C. Still that uses a stationary phase (a column or cartridge filled with an insoluble solid support) and a mobile phase (elution solvent mixture) to separate and purify a mixture of organic compounds.
Tags:
Brochures
Normal-phase flash chromatography1 has been widely adopted as the method of choice for separation of product mixtures and reaction by-products. One of the most significant developments in this
area concerns the practical separation of polar molecules. Reversed-phase purification is a modification of normalphase
chromatography that provides an efficient mechanism for the separation of polar compounds.
Tags:
Application Notes,
Brochures,
English,
Manuals & User Guides
User report: Flash instruments. Chugai Pharmaceutical uses Biotage flash chromatography products for drug discovery research. When deciding to convert from manual open-column procedures to automated systems, they chose successive generations of Biotage products, ranging from the Flash+® packed column to the Biotage® Horizon, SP1, Isolera™ Spektra, and Isolera™ Dalton automated flash chromatography systems.
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Customer Cases
Biotage®SNAP Ultra cartridges are compatible with CombiFlash® Rf Systems. As a convenience, Biotage SNAP Ultra cartridges with Luer slip connectors are available. Contact your Biotage representative for ordering information.
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Manuals & User Guides
The definitive guide to flash chromatography. This document presents in detail the broad selection of ways that materials for purification can be loaded onto a flash cartridge.
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Manuals & User Guides
Flash purification involves a simple liquid chromatography technique
» Method development uses TLC as a way of deciding the parameters for the
separation
» Isocratic separations are easiest to develop, but gradient separations are
more powerful
» Software in the Isolera helps with conversion of an isocratic separation to
a gradient
» It is possible with the Spektra software to run step gradients
» Loading options are dependent on the column type
» SNAP offers the most flexibility
» Care must be taken to choose the best loading option to get good
purifications
Tags:
Manuals & User Guides
Normal-phase flash chromatography1 has been widely adopted as the method of choice for separation of product mixtures and reaction by-products. One of the most significant developments in this
area concerns the practical separation of polar molecules. Reversed-phase purification is a modification of normalphase
chromatography that provides an efficient mechanism for the separation of polar compounds.
Tags:
Application Notes,
Brochures,
English,
Manuals & User Guides
Laboratory chemical
Not for therapeutic or diagnostic use
Tags:
English,
Material Safety Data Sheets
In medicinal chemistry, organic synthesis will generate by-products with similar chemistry to the product. Separating these impurities from the product often becomes a challenge that often only prep HPLC can achieve.
In this poster, we discuss how using sample dry loading with a cation exchange scavenger media with flash chromatography
improves product purity by removing many of the impurities.
Tags:
Posters
New, higher default flow rates enabled by Isolera ACI systems decreases purification times compared to other systems’ and cartridges’ default flow rate settings without sacrificing separation efficiency. Incorporation of gradient optimization by converting a linear gradient to a step gradient further reduces purification time and solvent use while maintaining separation integrity for a target molecule.
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Posters
SNAP Ultra cartridges increase purification throughput and product purity compared to larger standard silica cartridges.
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Posters
Bei herkömmlichen Aufreinigungsverfahren mittels Chromatographie kommen große Mengen verhältnismäßig giftiger und teurer Lösungsmittel zum Einsatz, die sich negativ auf den ökologischen Fußabdruck von Unternehmen in der Molekularforschung auswirken. Neue Richtlinien für einen verantwortungsvolleren Umgang mit Chemikalien zwingen Unternehmen, die Umweltauswirkungen ihrer Arbeit zu reduzieren. Durch Einblicke in die Arbeitsabläufe dieser Unternehmen und neue Entwicklungen im Bereich Flash-Chromatographiesysteme und -säulen lassen sich Verbrauch und Toxizität der für die Aufreinigung eingesetzten Lösungsmittel und somit auch die Umweltbelastungen dieser Verfahren reduzieren.
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Environmental,
German,
Product Notes,
White Papers
Traditional approaches to compound purification involving chromatography utilize large volumes of relatively toxic and expensive solvents, and significantly contribute to the environmental footprint of organizations involved in molecular research. Current directives for greener chemistry have put pressure on organizations to reduce the
environmental impact of their work.
Tags:
Environmental,
Product Notes,
White Papers
To save money on consumables, many chemists choose to reuse
silica flash cartridges. This is true but risks purification results because chromatographic separation performance will change from run to run which reduces purification quality, especially in normal phase systems.
Regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and therefore fraction purity.
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Product Notes
With running costs and time a concern in most labs, ACI™ now promises to take users to the end point even faster and even more efficiently.
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Product Notes
Precision engineered Biotage SNAP Ultra cartridges deliver double
the purification capacity utilizing small particle spherical silica with
an 40% increase in surface area. This proprietary silica reduces
peak width and provides higher concentration fractions with less
fraction volume.
Tags:
English,
Product Notes
Bei herkömmlichen Aufreinigungsverfahren mittels Chromatographie kommen große Mengen verhältnismäßig giftiger und teurer Lösungsmittel zum Einsatz, die sich negativ auf den ökologischen Fußabdruck von Unternehmen in der Molekularforschung auswirken. Neue Richtlinien für einen verantwortungsvolleren Umgang mit Chemikalien zwingen Unternehmen, die Umweltauswirkungen ihrer Arbeit zu reduzieren. Durch Einblicke in die Arbeitsabläufe dieser Unternehmen und neue Entwicklungen im Bereich Flash-Chromatographiesysteme und -säulen lassen sich Verbrauch und Toxizität der für die Aufreinigung eingesetzten Lösungsmittel und somit auch die Umweltbelastungen dieser Verfahren reduzieren.
Tags:
Environmental,
German,
Product Notes,
White Papers
Traditional approaches to compound purification involving chromatography utilize large volumes of relatively toxic and expensive solvents, and significantly contribute to the environmental footprint of organizations involved in molecular research. Current directives for greener chemistry have put pressure on organizations to reduce the
environmental impact of their work.
Tags:
Environmental,
Product Notes,
White Papers
Want to improve your flash chromatography skills? Learn all the tricks of the trade in this one-hour webinar with flash guru Bob Bickler. For a dedicated synthetic chemist, the goal ...
20 November 2017Although linear synthesis of protected peptides is generally straightforward, purification of these compounds using traditional reversed phase methods is quite challenging. A poster from ...
25 October 2017Models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent. Today, chemists multitask to be more efficient, but this does not reduce the actual time t...
19 October 2017Developments in instrumentation and consumables around Flash purification can reduce solvent consumption levels of a typical drug discovery workflow by 50% or more. This is achieved ...
31 May 2017"Normal-phase silica has, on average, 50 to 60 Å pores (and a surface area of 500 m²/g). However, for small-molecule reversed-phase chromatography to be useful, the average pore siz...
07 November 2016Senior Technical Specialist Bob Bickler digs into the limiting factors for sample load in flash chromatography on the Flash Purification Blog. "A question I hear a lot from chemists ...
18 March 2016The industry standard platform for flash purification, Isolera™, is given a basic presentation by our German account manager in this short video. Isolera™ ist ein Flash C...
04 March 2016This application note describes a simple and robust way to swap to more environmentally friendly solvents in flash purification. In this application, Biotage® SNAP Ultra 25 g cartridges ar...
02 March 2016The term column volume, typically abbreviated CV, is a value used to help determine separation quality and loading capacity. But how can this concept and its definition be better understood? Bob Bi...
13 November 2015This blog post on the Flash Purification Blog discusses the process of simplified flash purification scale-up. For many chemists performing bench-scale organic synthesis, flash column chro...
16 September 2015ACI™ - Accelerated Chromatographic Isolation is a revolutionary advancement converting regular flash from simple purification to the fastest, greenest, and most economical way to reliably iso...
11 September 2015A new post on the Flash Purification Blog addresses the question "Normal or reversed phase in flash chromatography". There is nothing more important to purification success with chromatogr...
01 September 2015Techincal specialist Bob Bickler goes through a good method to optimize column size for your purification in his latest blog post on The Flash Purification Blog. "In all my years of work...
30 June 2015Biotage® SNAP Ultra flash cartridges allow you to load your samples in seven different ways. No matter what you are purifying - there is always a solution to get the best possible separati...
22 May 2015"The real benefit of this column is that it has a much higher loading, up to 4 times the amount you would get on a normal column". Dr. Greg Saunders explains all the benefits of using a Biotage®...
24 April 2015Japanese chemical detectives have used Isolera™ Dalton mass-driven flash chromatography system and Biotage® SNAP Ultra flash cartridges to identify the origins of traditional medicin...
27 March 2015Biotage, pioneers in flash chromatography, started packing columns with silica for flash purification 30 years ago. Some of the first employees are still with us today. In this video, site director...
11 March 2015Chugai Pharmaceutical in Japan have worked through nearly every piece of flash equipment from Biotage. Here they explain why - and what they expect from the future. Three research ch...
04 February 2015Biotage will attend the 22nd SCT Young Researchers in Paris, France 4-6 February 2015 Read More http://www2.sct-asso.fr/form.php?langue=english&cle_menus=1187970162
16 December 2014Users running flash chromatography systems other than Isolera™ can still benefit from the high performance of Biotage® SNAP Ultra flash cartridges. Biotage®SNAP Ultra cartrid...
04 December 2014Regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and fraction purity. To save money on consumables, many chemists choo...
20 November 2014Which cartridge should I use? How do different silica gels influence my purification? What is the correlation between the Rf value and column volume? What's the difference between isocratic and ste...
13 October 2014Fragrance compounds, being invisible to UV, can be elusive and difficult to isolate. In this application, a four component mixture of fragrance compounds was purified using Accelerated Chromatograp...
12 September 2014The capabilities of Biotage flash chromatography systems for providing pure compounds from natural products is confirmed in an extensive Korean study of active compounds in the medicinal herb&...
06 August 2014Fatty acids and their esters are found in many biological substrates. Many of these fats are unhealthy (e.g. saturated fats) while others have been found to be beneficial (e.g. unsaturated, polyuns...
29 July 2014Buy your Biotage consumables through our website and shipping is free For a limited time, free shipping is applied to Biotage consumables orders through the Biotage website*. Let Biotage make orde...
27 June 2014Uppsala, Sweden, 27th June, 2014 – Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the launch of ACI&trad...
14 March 2014By Dr. Greg Saunders, EU Marketing Manager for Organic and Peptide Chemistry at Biotage Liquid chromatography (LC) is used for two different purposes – analytical work and purification &ndas...
31 January 2012Introducing the new Biotage® SNAP Ultra high performance flash chromatography cartridges utilizing Biotage® HP-Sphere™ spherical silica. Uppsala, Sweden, January 31, 2012 &nd...
18 October 2011Preparative FLASH chromatography expedites the production of clinical trial compounds. Tobi Williams is an application chemist specializing in pilot and production purification at Biotag...
Part No. | Description | Product type | Pack Size | Price | ||
413127 | DLV-030 and -070 holder four use with SNAP 10g through 100g cartridges | Accessories | 1 | Log in for price | ||
413128 | DLV-030 and -070 holder for use with SNAP 340g cartridges | Accessories | 1 | Log in for price | ||
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DLV-030 | Dry load vessel kit, 30g | Accessories | 1 | Log in for price | |
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DLV-070 | Dry load vessel kit, 70g | Accessories | 1 | Log in for price |