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Biotage^® PS-Carbodiimide

Coupling Agent for Amide and Ester Synthesis, Formation of Pentafluorophenyl (PFP) and Other Activated Esters

Biotage® PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. In general, PS-Carbodiimide was found to synthesize amides in high yield and purity without evidence of residual amine or carboxylic acid. Unreacted carboxylic acid, normally used in excess relative to the amine, remains bound to the resin during workup.

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Biotage® PS-Carbodiimide Product Note

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Part numbers

Part No.	Description	Pack Size	List Price
800372	Biotage® PS-Carbodiimide, 1 kg	1		Add to quote/cart
800369	Biotage® PS-Carbodiimide, 10 g	1	229 USD	Add to quote/cart
800371	Biotage® PS-Carbodiimide, 100 g	1	1810 USD	Add to quote/cart
800370	Biotage® PS-Carbodiimide, 25 g	1	515 USD	Add to quote/cart
800508	Biotage® PS-Carbodiimide, 3 g	1	91 USD	Add to quote/cart

Specifications

RESIN TYPE 1% Cross-linked poly(styrene-codivinylbenzene)

CHEMICAL NAME N-Cyclohexylcarbodiimide-Npropyloxymethyl

APPLICATION Coupling agent for amide and ester synthesis, formation of pentafluorophenyl (PFP) and other activated esters

COMPATIBLE SOLVENTS DCM (7.0 mL/g), DCE (7.4 mL/g), THF (6.9 mL/g), toluene (4.5 mL/g), and other solvents that swell polystyrene

BULK DENISTY 350g /L

TYPICAL CONDITIONS FOR COUPLING 2 equivalents of resin, 1.5 equivalent of acid, 1.0 equivalent of amine in DCM overnight at room temperature

STORAGE Cool dry / closed container

SHELF-LIFE / RETEST DATE 1 year

CAPACITY 1.0 - 1.3 mmol/g

PARTICLE SIZE 75-150 microns

Biotage® PS-Carbodiimide Product Note

Benefits

For over 15 years Biotage has been guiding and leading the industry in supported reagents and scavengers. PS-Carbodiimide is very stable and lost less than 5% of its initial activity when stored at 4 ˚C for 2 years. This is due to increased stabilization provided by the ether linkage. Unlike inferior copies, the carbodiimide moiety in Biotage PS-Carbodiimide is not Benzylic by design.

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Efficiently deliver chemistry

More effective than traditional methods, polymer supported chemistry has been used widely in applications for over fifty years. Biotage supported reagents and scavengers are based on functionalized polystyrene or silica polymers and are 100% insoluble, therefore can be added to reactions and completely removed afterwards.

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Industry Proven

Key supplier to industry for over 15 years, used in numerous patents and cGMP process campaigns

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Robust, reliable, scalable and safe

From grams in research through to multi kilogram quantities in production campaigns. In general, PS-Carbodiimide was found to synthesize amides in high yield and purity without evidence of residual amine or carboxylic acid. Unreacted carboxylic acid, normally used in excess relative to the amine, remains bound to the resin during workup.

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Fully Documented and Quality Assured

Inert, specifically-reactive and deployed to achieve a specific purpose. With lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement, these resins also support the audit trail.

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Biotage^® PS-Carbodiimide

Coupling Agent for Amide and Ester Synthesis, Formation of Pentafluorophenyl (PFP) and Other Activated Esters

Part numbers

Literature

Specifications