Evaporative crosstalk is well-to-well cross contamination during extract evaporation after SLE or SPE extraction in a 96 well plate. It is often observed with volatile analytes like methamphetamine and amphetamine, but it can also occur with other drugs and metabolites when urine samples have very high analyte concentrations. The Biotage® ACT Plate Adapter helps to control evaporative crosstalk, however in samples with very high concentrations, additional measures in addition to the ACT Plate Adapter should be considered.
Literature number: P220.V.1