Functionalized pipette tips have been available for many years. Marketed for solid phase extraction, these pipette tips carry a solid phase contained within a polymer precipitate located at the end of the tip. In more recent development, pipette tip columns carrying conventional chromatographic media packed into beds between frits, have found use improving R&D productivity and capability in academic and industrial settings. In pipette tip columns (PhyTip Columns), sample and mobile phase enter and exit the same end. All liquid flow is bidirectional including sample loading, dilution of contaminants and elution of desired materials in a manner we call Dual Flow Chromatography (DFC).
Literature number: P205