Dilute and shoot (D/S) is the most common form of sample preparation for the analysis of drugs of abuse in urine. High analyte cut-offs combined with sensitive mass spectrometers allow substantial sample dilution while still reaching desired limits of quantitation. However, this technique presents various issues resulting in increased MS downtime. This poster evaluates the extraction of a range of drugs of abuse from hydrolysed and non- hydrolysed urine using a novel flow through scavenging product, ISOLUTE® HYDRO DME+. Matrix component removal in terms of creatinine and urea, salt residue, pigmentation associated with urobilin content and protein removal will be demonstrated.
Literature number: P178.V.4