---
title: Evaluation of a novel SPE sorbent for the extraction of oligonucleotides from biological matrices
description: This poster demonstrates the applicability of a novel SPE sorbent to the extraction and analysis of oligos from biomatrices.
---

[Literature ](https://www.biotage.com/literature)

# [Evaluation of a novel SPE sorbent for the extraction of oligonucleotides from biological matrices](https://www.biotage.com/literature/poster/evaluation-novel-spe-sorbent-extraction-oligonucleotides-biological-matrices)

 Written by [Biotage](https://www.biotage.com/literature/author/biotage) | Feb 24, 2026 12:24:04 PM

This poster investigates the use of a novel polymerbased mixed-mode weak anion exchange solid phase extraction sorbent for improved oligonucleotide detection from various biological matrices. Method performance was evaluated using plasma, urine and liver matrices and assessed for ASO extraction efficiency and overall extract cleanliness.

 

Literature number: P277.V.2

[View full post](https://www.biotage.com/literature/poster/evaluation-novel-spe-sorbent-extraction-oligonucleotides-biological-matrices)

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