---
title: "Method development guidelines: SPE using ISOLUTE® CBA sorbents for the extraction of aqueous samples"
description: The ISOLUTE® family of cation exchange sorbents are used to extract organic cations from both aqueous and non-aqueous matrixes.
---

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# [Method development guidelines: SPE using ISOLUTE® CBA sorbents for the extraction of aqueous samples](https://www.biotage.com/literature/technical-note/method-development-guidelines-spe-isolute-cba-aqueous-samples)

 Written by [Biotage](https://www.biotage.com/literature/author/biotage) | Dec 6, 2025 7:00:00 AM

The ISOLUTE® family of cation exchange sorbents are used to extract organic cations (basic compounds capable of exhibiting a positive charge) from both aqueous and non-aqueous matrixes. Although extraction is by the same mechanism, each sorbent has properties that influence the way they are used.

Literature number: TN108

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