---
title: "Method development guidelines: SPE using ISOLUTE® NH2 SPE sorbents for the extraction of aqueous samples"
description: The ISOLUTE® family of anion exchange sorbents are used to extract organic anions from both aqueous and non-aqueous matrixes.
---

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# [Method development guidelines: SPE using ISOLUTE® NH2 SPE sorbents for the extraction of aqueous samples](https://www.biotage.com/literature/technical-note/method-development-guidelines-spe-isolute-nh2-aqueous-samples)

 Written by [Biotage](https://www.biotage.com/literature/author/biotage) | Dec 6, 2025 2:00:00 AM

The ISOLUTE® family of anion exchange sorbents are used to extract organic anions (acidic compounds capable of exhibiting a negative charge) from both aqueous and non-aqueous matrixes.

Literature number: TN104.V.1

[View full post](https://www.biotage.com/literature/technical-note/method-development-guidelines-spe-isolute-nh2-aqueous-samples)

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