---
title: Optimized evaporation in oligonucleotide sample preparation
description: Sample concentration through evaporation can improve analytical sensitivity and ensure more consistent and reliable detection of oligonucleotides.
---

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# [Optimized evaporation in oligonucleotide sample preparation](https://www.biotage.com/literature/technical-note/optimized-evaporation-oligonucleotide-sample-preparation)

 Written by [Biotage](https://www.biotage.com/literature/author/biotage) | Feb 23, 2026 10:51:49 AM

Evaporation is often used during preparation of oligonucleotide samples before LC-MS/MS to remove excess solvents, buffers, or volatile reagents. By concentrating the sample and exchanging it into a more MS-friendly solvent, evaporation can improve analytical sensitivity and ensure more consistent and reliable detection of oligonucleotides during analysis.

Literature number: TN202

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