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    BIOMARK2.372 - SM In Well

    Current Methodologies for Drugs of Abuse Urine Testing

    This white paper examines a number of aspects of sample preparation, and their impact on the success of subsequent LC-MS/MS analysis of broad urine panels. Originally published in 2017, the white paper has now been updated to include details of additional hydrolysis enzymes and optimum hydrolysis conditions.

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    Extraction of Tobacco-Specific Nitrosamines (TSNAs) from Urine

    This application note describes a method for extracting nitrosamines from urine. The ISOLUTE® SLE+ sample preparation method allows for a fast extraction with sufficient sample clean up, resulting in clean extracts.

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    In-well Hydrolysis: Streamline Your Sample Handling

    Save time and eliminate sample transfer steps, reducing the risk of errors and improving method robustness.  This application note describes the extraction and clean up of 96 licit and illicit drugs using in-well hydrolysis of the urine sample.

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    Urine Hydrolysis: Does it matter how you do it?

    Urine hydrolysis is performed to eliminate glucuronide drug metabolites before analysis, and it is key part of the sample preparation process. But it can involve extra sample transfer steps, and adds time to the sample preparation process. Streamline your workflow with integral in-well hydrolysis.

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    Resources
    Selection of clinical sample preparation applications from Biotage.
    Method development chart, tips and tricks and useful insights to optimize your sample prep.
    Eliminate carryover between samples, and reduce the risk of false positive results. 

    Advances in Sample Prep Using In-well Hydrolysis.

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