Sample Preparation Method for Determination of Axitinib in Plasma Using ISOLUTE® SLE+

Axitinib is a type of molecularly targeted drug used in renal cell carcinoma. To avoid serious side effects and achieve maximal therapeutic efficacy, it is crucial to determine the correlation between side effects on blood levels and treatment efficacy. Therapeutic Drug Monitoring (TDM) is one of the measures to achieve this. In this application note, ISOLUTE® SLE+ was used as a sample preparation column for Axitinib determination in plasma using the principles of supported liquid extraction (SLE).