|Temperature||40-250 °C (104-482 °F)|
|Temperature increase||2-5 °C/sec (3.6-9 °F/sec)|
|Pressure range||0-20 bar (2 MPa, 290 PSI)|
|Power range||0-400 W at 2.45 GHz|
|Reaction vials||4 sizes: 0.2-0.5, 0.5-2, 2-5, 10-20 mL|
|Vial volume range||0.2-20 mL (EXP) 0.5-5 mL|
|Agitation||Variable magnetic stirrer (300-900 RPM)|
|Sample Processor||upgradeable with Robot Eight/ Robot Sixty|
|Processing capacity||8 vials / 60 vials|
|Rack capacity (large)||2x2 vials / 2x12 vials|
|Rack capacity (small)||2x4 vials / 2x30 vials|
|Temperature||18-32 °C (65-90°F)|
|Electrical supply||EU: 220-240 V, 50 Hz (5 A) US: 120 V, 60 Hz (10 A) JP: 100V, 5|
|Maximum power consumed||1000 VA|
|Pressurized air supply (reaction cooling) Cooling||Pressurized air supply >60 L/min (2.1 cubic feet/min), 2.5 – 4 b|
|Weight Dimensions||48.9 lb (22.2 kg) 14.4” x 15.9” x 16.3” W x D x H (365mm x 405mm|
|Ethernet LAN||Complies with IEEE 802.3 (ANSI 8802.3) MII|
|Archiving/Backup & Printing||Via the LAN, Biotage HUB, USB memory stick, or direct connection|
|Upgrade Path||The Initiator system can be upgraded to an 8 or 60-position sys|
|Certifications||CE, CSA certified|
Customer Case: ISIR, Osaka University
Tags: Customer Cases
User report: Initiator. Prof. Nakamura at the Gakushuin University has described the Initiator as an essential tool for his group’s cutting-edge research. We asked Prof. Nakamura for his views on the latest trends in the fields of organic synthesis and drug discovery.
Tags: Customer Cases
Translated versions of the Safety chapter available in the Biotage® Initiator Installation and Safety document (P/N 355976). Languages: Danish, Dutch, Finnish, French, German, Italian, Japanese, Spanish, and Swedish.
Tags: Danish, Dutch, Finnish, French, German, Italian, Japanese, Manuals & User Guides, Spanish, Swedish
The trend pharma industry is clearly to speed up the process from lead identification to selection of candidate drug. One of the major limitations is the availability of larger amounts typically hundreds of grams, of the potentially active substance to be further investigated
One very common transformation in organic synthesis is the reduction of aldehydes or ketones to the corresponding primary or secondary alcohols (Scheme 1) using sodium borohydride as hydride donator. This reaction generally generates the product in very high yield. Among the draw-backs are long reaction times, that a large excess of reagent is needed and that the reaction mixture must be extracted in order to separate the inorganic salts from the product.
The formation of 2,5-diketopiperazines from a water suspension of N-Boc protected dipeptide alkyl esters or dipeptide alkyl esters was induced by microwave assisted heating (Scheme 1). The products, which precipitated, were obtained in good yields. However, epimerisation/diastereomer formation was found to various extents depending on the amino acid sequence and the applied reaction temperature.
Biotage® Initiator+ represents the latest in microwave synthesis performance. This instrument’s high-end specifications enable the chemist to explore new areas and perform the latest of innovations in chemistry. A reliable and upgradeable platform that allows chemists to make great discoveries in less time.
Durable and safe reactions at all times. Our high precision microwave vials are designed and tested to withstand pressures beyond 30 bar in a wide range of conditions.
Biotage® PathFinder is the largest existing database of verified methods for microwave synthesis. This unique web- based service features more than 5,000 selected microwave reactions and knowledge support.